Author

C. L. Maikawa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 12 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 13 Organism:mouse· 8 Research Focus:drug response / drug discovery· 6 Research Focus:cancer & tumor microenvironment· 4 Organism:rat· 4 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

E. A. Appel· 10 shared A. K. Grosskopf· 5 shared J. L. Mann· 5 shared A. I. d'Aquino· 4 shared C. K. Jons· 3 shared E. C. Gale· 3 shared L. T. Nguyen· 3 shared S. Correa· 3 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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10 shared papersBioengineering

E. A. Appel

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Author profile →

13 papers

Recent·Most cited

Cancer Immunotherapy through Tissue Adhering Polymers

N. J. Borthwick, C. L. Maikawa, S. Weller, T. L. Andresen, A. E. Hansen, A. A. A. Autzen

This study develops a copolymer to control the localization of TLR 7/8 agonists, achieving prolonged tumor retention and curative effects in a murine model.

bioRxiv · Mar 23, 2023 · PreprintCancer Biology

Sustained Delivery of GLP-1 Receptor Agonists from Injectable Biomimetic Hydrogels Improves Treatment of Diabetes

A. I. d'Aquino, C. L. Maikawa, L. T. Nguyen, K. Lu, I. A. Hall, C. K. Jons, C. I. Kasse, J. Yan, A. N. Prossnitz, E. Chang, S. W. Baker, L. Hovgaard, D. B. Steensgaard, H. B. Andersen, L. Simonsen, E. A. Appel

This paper develops a hydrogel-based GLP-1 receptor agonist delivery system that provides sustained therapy for up to 42 days in rats, improving diabetes management compared to daily injections.

bioRxiv · Jan 28, 2023 · PreprintBioengineering

Polyacrylamide-based Hydrogel Coatings Improve Biocompatibility of Implanted Pump Devices

D. Chan, C. L. Maikawa, A. I. d'Aquino, S. S. Raghavan, M. L. Troxell, E. A. Appel

This study develops polyacrylamide-based hydrogel coatings that improve the biocompatibility of implanted medical devices, extending their functional lifetime in animal models.

bioRxiv · Dec 13, 2022Bioengineering

Formulation excipients and their role in insulin stability and association state in formulation

C. L. Maikawa, L. T. Nguyen, J. L. Mann, E. A. Appel

This study investigates how excipients affect insulin stability and association state, finding that phenoxyethanol and specific copolymer concentrations enhance monomer content and stability in zinc-free insulin formulations.

bioRxiv · Aug 1, 2022Bioengineering

Subcutaneous delivery of an antibody against SARS-CoV-2 from a supramolecular hydrogel depot

C. M. Kasse, A. C. Yu, A. E. Powell, G. A. Roth, C. S. Liong, C. K. Jons, A. Buahin, C. L. Maikawa, S. Youssef, J. E. Glanville, E. A. Appel

This paper develops a supramolecular hydrogel depot for subcutaneous delivery of SARS-CoV-2 bnAbs, showing prolonged release and improved pharmacokinetics compared to standard administration.

bioRxiv · May 24, 2022Bioengineering

Delivery of CAR-T Cells in a Transient Injectable Stimulatory Hydrogel Niche Improves Treatment of Solid Tumors

A. K. Grosskopf, L. Labanieh, D. D. Klysz, G. Roth, P. Xu, O. Adebowale, E. C. G. C. Gale, C. K. Jons, J. H. Klich, J. Yan, C. L. Maikawa, S. Correa, B. S. Ou, A. I. d'Aquino, J. R. Cochran, , E. Appel

This paper develops an injectable hydrogel to co-deliver CAR-T cells and cytokines, enhancing solid tumor treatment in mice by creating a transient inflammatory niche.

bioRxiv · Dec 20, 2021Bioengineering

Injectable Nanoparticle-Based Hydrogels Enable the Safe and Effective Deployment of Immunostimulatory CD40 Agonist Antibodies

S. Correa, E. C. Gale, A. T. Mayer, Z. Xiao, C. Liong, J. H. Klich, R. A. Brown, E. L. Meany, O. M. Saouaf, C. L. Maikawa, A. K. Grosskopf, J. L. Mann, J. Idoyaga, E. Appel

This paper develops injectable hydrogels to safely deliver CD40 agonist antibodies, reducing toxicity while maintaining anti-cancer efficacy in a melanoma model.

bioRxiv · Jun 27, 2021Bioengineering

Consistent Tumorigenesis with Self-Assembled Hydrogels Enables High-powered Murine Cancer Studies

A. K. Grosskopf, S. Correa, J. Baillet, C. L. Maikawa, E. C. Gale, R. A. Brown, E. A. Appel

This paper introduces a hydrogel-based tumor inoculation method that reduces variability in murine tumor growth, enabling more efficient and reliable cancer studies.

bioRxiv · Apr 13, 2021Bioengineering

Engineering Insulin Cold Chain Resilience to Improve Global Access

C. L. Maikawa, J. L. Mann, A. Kannan, C. M. Meis, A. K. Grosskopf, B. S. Ou, A. A. A. Smith, G. G. Fuller, D. M. Maahs, E. A. Appel

This paper develops amphiphilic copolymers to enhance insulin formulation resilience, enabling storage without refrigeration for over 6 months and improving global access to insulin.

bioRxiv · Apr 13, 2021Bioengineering

Ultra-fast insulin-pramlintide co-formulation for improved glucose management in diabetic rats

C. L. Maikawa, P. C. Chen, E. T. Vuong, L. T. Nguyen, J. L. Mann, A. I. d'Aquino, R. A. Lal, D. M. Maahs, B. A. Buckingham, E. A. Appel

This study develops an ultra-fast insulin-pramlintide co-formulation that improves glucose management in diabetic rats by mimicking endogenous co-secretion and reducing patient burden.

bioRxiv · Apr 12, 2021Bioengineering

Injectable hydrogels for sustained co-delivery of subunit vaccines enhance humoral immunity

G. A. Roth, E. C. Gale, M. Alcantara-Hernandez, W. Luo, E. Axpe, R. Verma, Q. Yin, A. C. Yu, H. Lopez Hernandez, C. L. Maikawa, A. A. A. Smith, M. M. Davis, B. Pulendran, J. Idoyaga, E. A. Appel

This paper introduces an injectable hydrogel platform for sustained co-delivery of subunit vaccines, which enhances humoral immunity by improving antigen and adjuvant presentation over time.

bioRxiv · May 26, 2020Bioengineering

Combinatorial Polyacrylamide Hydrogels for Preventing Biofouling on Implantable Biosensors

D. Chan, J.-C. Chien, E. Axpe, L. Blankemeier, S. W. Baker, S. Swaminathan, V. A. Piunova, D. Y. Zubarev, C. L. Maikawa, A. K. Grosskopf, J. L. Mann, H. T. Soh, E. A. Appel

This study develops combinatorial polyacrylamide hydrogels that outperform current anti-biofouling coatings in preventing biofouling on biosensors.

bioRxiv · May 25, 2020Bioengineering

Continuous detection of glucose and insulin in live animals

M. Poudineh, C. L. Maikawa, E. Yue Ma, J. Pan, D. Mamerow, Y. Han, S. w. Baker, A. Beirami, M. Eisenstein, S. Kim, J. Vuckovic, E. A. Appel, H. T. Soh

This paper develops a biosensor capable of continuously measuring multiple analytes in live animals with high sensitivity and temporal resolution, demonstrating its use for glucose and insulin detection in diabetic rats.

bioRxiv · Jan 22, 2020 · PreprintBioengineering