J. Li

This paper introduces a transformation-free confocal staining technique for visualizing plant-fungal interactions and uses machine learning to quantify fungal volume and nuclear breakdown.

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

The paper identifies two European bat MERS-related coronaviruses that use ACE2 as their receptor, revealing a distinct binding mode and host tropism determinants.

This paper introduces Spiral NeuroString, high-density soft bioelectronic fibers for multimodal sensing and stimulation, demonstrating their use in GI motility mapping, serotonin sensing, and brain recordings.

This study identifies VCP/p97 as an obligate co-factor of ASPSCR1-TFE3, showing it organizes enhancer loops to drive oncogenic transcription in ASPS and RCC.

This study identifies Upc2 as a key regulator of azole resistance in C. auris by modulating ERG11 expression and the Mrr1/Mdr1 pathway.

This study maps disease-associated missense mutations in voltage-gated sodium channels and shows that their effects on channel function are more nuanced than traditional gain-of-function or loss-of-function classifications.

This study examines gene expression changes in CD8 T cells from HCV-infected individuals with varying fibrosis stages, identifying lasting hyperfunction and upregulated Hedgehog signaling in cirrhosis.

This study shows that chronic liver fibrosis leads to systemic CD8+ T cell hyperfunction, impairing tumor control and immune response.

This paper demonstrates that acetosyringone, a plant phenolic, can induce gene expression in E. coli's OxyRS regulon when oxidized via electrode potential, expanding electronic control of microbial responses.

This paper combines nanoparticle-delivered immune agonists with senescence-inducing agents to enhance T cell responses and control pancreatic cancer in preclinical models.

This study identifies ULK1-mediated phosphorylation of PKM2 that inhibits O-GlcNAcylation and reduces the Warburg effect in breast cancer.

This study evaluates the neutralization efficacy of a tetravalent vaccine booster against emerging SARS-CoV-2 variants, finding it induces higher neutralizing titers than breakthrough infection.

This study identifies O-GlcNAcylation of YTHDF2 at Thr-49 as a regulator of ERK-dependent phosphorylation and tumor growth in lung carcinoma.

This study identifies ABA and BR as key regulators in overcoming inter-subgeneric hybridization barriers in water lily through transcriptomic and hormonal analyses.

This study shows that regulating temperature and humidity in greenhouses can reduce tomato disease severity by affecting gene expression and pathogen toxin production.

The paper analyzes the virome of 2,438 individual mosquitoes across China to reveal viral diversity, geographic hotspots, and the impact of host phylogeny on viral composition.

This paper develops 3D printed scaffolds with MXene coatings to guide neuronal growth and enable photothermal stimulation for neural circuit engineering.

The paper introduces enGager, a system that enhances ssDNA-mediated genome integration by fusing Cas9 with ssDNA-binding proteins, achieving up to 6-fold efficiency improvements for large transgene knock-in.

This study demonstrates nitrate-dependent anaerobic oxidation of ethane and butane by Candidatus Alkanivorans nitratireducens, revealing the fumarate addition pathway's role in SCGA metabolism.

This study examines SNCA transcription in neurons with different -syn cytopathologies in LBD, finding preserved transcripts in non-Lewy body types and reduced in Lewy bodies.

This study shows that oxytocin reduces colitis and CAC by enhancing MUC2 fucosylation via OXTR, suggesting it as a potential therapeutic for these conditions.

This study evaluates Yaq-001, a non-absorbable carbon bead, in rodent cirrhosis and ACLF models, showing improvements in inflammation, liver function, and microbiome composition.

This study establishes a canine model for echocardiography-guided percutaneous intramyocardial septal cryoablation and shows its safety and feasibility in reducing interventricular septum.

This study identifies CDK8 and CDK19 as drivers of androgen-independent growth in castration-resistant prostate cancer and shows that their inhibition can suppress tumor growth and induce regression.

This study shows that combining ketogenic diet and HDAC inhibitors with ICB therapy enhances anti-tumor effects in prostate cancer by modulating epigenetic and immune mechanisms.

This study identifies a genetic basis for cancer sex differences in Xp11 translocation renal cell carcinoma by showing a 2:1 female:male ratio in TFE3 fusions involving the inactive X chromosome.

The paper shows that inhibiting NaV1.6 reduces seizures in both wild-type and Scn8aN1768D/+ mice, suggesting NaV1.6 is a key target for anti-seizure drugs.

This paper identifies a novel bacterial pathway for sulfofucose catabolism in Paracoccus wurundjeri, involving a sulfofucolytic Entner-Doudoroff pathway and subsequent biomineralization to sulfite.