J. Li

The paper develops a Bayesian framework to analyze multi-species functional response experiments, identifying optimal experimental designs and demonstrating robust model selection despite noise.

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

The paper determines the structure of ARF6 protein lattice on tubulated membranes, revealing its role in vesicle fission and how GAP proteins interact with it.

This study shows that primary cilia in osteoblasts and osteocytes are essential for skeletal development and mechanotransduction, as demonstrated by reduced bone growth and impaired mechanical loading response in knockout mice.

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

This study investigates how MutSβ binds to long extruded DNA trinucleotide repeats and identifies compounds that block this interaction without affecting mismatched DNA.

This paper introduces an electronic detection method to identify structural perturbations in proteins by measuring mediator-accessible redox activities, demonstrating its application in biomanufacturing.

This paper evaluates a novel simian adenovirus vectored COVID-19 vaccine, showing that intranasal vaccination induces stronger mucosal immunity while intramuscular vaccination enhances systemic immunity, with combined regimens providing long-term protection.

This study evaluates five slow-controlled release fertilizers on rice quality over two years, finding that BBF improves yield and grain quality by optimizing carbon-nitrogen metabolism.

The paper investigates how Arp2/3 complex and formins cooperate to maintain the cortical actin array in Arabidopsis epidermal cells through single filament dynamics and genetic inhibition.

This study identifies XeAvrRxo1 as a virulence and avirulence effector in X. euvesicatoria and shows that its chaperone Xe4429 suppresses toxicity, represses expression, and enhances secretion of XeAvrRxo1.

This study compares transcriptomics, proteomics, and phosphoproteomics responses in HepG2 and AC16 cells to chemical exposure, finding phosphoproteomics changes occur earlier and at lower concentrations than transcriptomics.

This study shows that SARS-CoV-2 mAb treatment shifts memory B cell epitope recognition, affecting their response to vaccination.

This study shows TIPE promotes glycolysis and stemness in melanoma by interacting with PKM2 and activating HIF-1α through phosphorylation.

This study shows that combining DP2 antagonism with corticosteroids reduces the effectiveness of DP2 antagonism in treating chronic asthma by suppressing PGD2 and IFN-γ production.

The paper tracks behavioral development in gerbils using machine learning to identify distinct trajectories for food/water acquisition, exploration, and social behaviors, correlating with neural maturation.

The paper constructs a comprehensive lipid metabolism gene database for nine oilseed crops by integrating multi-omics data and identifying 221 additional genes.

This study quantifies how temperature and methane monooxygenase enzymes affect clumped isotope signatures in aerobic methane oxidation by Methylococcus capsulatus (Bath).

This study identifies pyrimethamine as an NRF2 inhibitor that suppresses esophageal hyperplasia in a mouse model and shows potential for clinical use in NRF2-high ESCC.

This study compares the effects of EFV and DTG on gut microbiome and intestinal barrier function in mice, finding both drugs impair gut barrier integrity, with EFV causing more severe metabolic and structural changes.

This paper describes a targeted protein degradation strategy using UNC8732 to recruit FBXO22 for NSD2 degradation, leading to growth suppression and reversal of drug resistance in leukemia cells.

This study identifies three eRNA biomarkers for hepatocellular carcinoma (HCC) and shows their involvement in cancer progression, prognosis, and potential as therapeutic targets.

This study investigates how social rank affects the integration of attributes in altruistic decisions, finding that social rank modulates attribute timing but not weights.

This study constructs a pan-genome of Brassica oleracea to uncover genomic basis of domestication and organogenesis differences among morphotypes.

The paper shows iron and magnesium limitations control distinct Salmonella subsets during infection in mice.

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

This paper develops protein-protein hydrogels using thiolation and Ag-S bonding to enhance wound healing properties in both diabetic and UV-burn models.

The paper identifies a mesenchymal-hepatocyte hybrid population that drives liver regeneration by regenerating 50% of new hepatocytes and repopulating liver zones 1 and 3.

The paper develops a standardized histopathologic evaluation approach for synovial membrane in murine OA models, showing good inter-reader agreement and consistent findings across stains.

This study identifies RBPm1 as a splicing activator essential for axoneme assembly in Plasmodium male gametogenesis, revealing an intron splicing program critical for male development.