J. Li

The paper shows that dMMR tumor cells are resistant to membrane damage but sensitive to IFN-γ and TNF-α co-treatment inducing PANoptosis, suggesting a strategy to enhance ICB therapy.

The paper introduces LDRS, a tool for generating conformational ensembles of intrinsically disordered regions in proteins, improving structural modeling of flexible segments.

The paper constructs gene catalogs and metagenome-assembled genomes from the swine lower respiratory tract microbiome and identifies associations between microbial species and lung lesions.

This study shows PSTPIP2 reduces kidney damage in AAN by suppressing IL-19-mediated NET formation and inflammation.

This study identifies a plant-microbe interaction system where a rhizosphere bacterium produces molecules with dual antibiotic and herbicide functions, offering insights into novel natural product discovery.

This study identifies SMU_1361c as a transcriptional repressor regulating oxidative stress response in Streptococcus mutans, showing its role in pathogenesis and potential for therapeutic development.

This paper demonstrates neuromorphic cytometry for cell counting and size estimation, achieving consistent results with traditional flow cytometry for microparticles and THP-1 cells.

The paper identifies a recombinant human astrovirus type 5 strain from an acute gastroenteritis outbreak in Beijing, China, showing genetic clustering with HAstV-1 and HAstV-5.

The paper identifies that specific prostaglandins, PGE2 and PGF2, are produced in Drosophila border cells and their surrounding substrate to promote collective migration.

This paper uses nanopore measurements to determine the size and shape of single α-synuclein oligomers in solution, revealing stable sub-populations with specific monomer counts.

This study identifies a temperature receptor and miRNA pathway that mediates the seasonal morphological transition in Cacopsylla chinensis.

This study shows that NVP-HSP990, a HSP90 inhibitor, effectively reduces rotavirus infection in vitro and in mice by inhibiting replication and alleviating intestinal damage.

This paper introduces a liquid-liquid interface system to model in vivo neutrophil migration, finding that neutrophils use bleb-based force generation to deform barriers under confining pressures.

This paper designs highly selective miniprotein inhibitors for integrins αvβ6 and αvβ8 with picomolar affinity and therapeutic potential in a mouse fibrosis model.

The paper investigates the evolution of a gene regulatory network in amphioxus, showing that enhancer hijacking allowed a new GRN to emerge through the functional shift of Gdf1/3-like to replace Gdf1/3 in axial development.

This study identifies ASFV p72 trimers as pH-sensitive structures that depolymerize in acidic endosomal conditions, explaining the pH-dependent uncoating mechanism of ASFV.

This study identifies a conserved binding pocket in class B GPCRs that enables small molecule agonists like PCO371 to activate G proteins without triggering arrestin signaling.

The paper presents high-resolution cryo-EM structures of mouse radial spokes and cryo-ET maps of ependymal cilia, revealing structural features and mutations linked to ciliary disorders.

The paper develops a method to enrich cells with high extracellular vesicle secretion and shows improved therapeutic outcomes in a mouse model.

This study develops a genetically encoded redox-responsive collagen-like protein hydrogel that accelerates diabetic wound healing by enhancing cell viability and reducing oxidant stress.

This study uses single-nucleus RNA sequencing to create a cell atlas of deep-sea mussel gills, revealing cell types and their roles in supporting chemosynthetic symbiosis and environmental adaptation.

This study shows that intestinal microbiota enhances the anti-tumor effect of oncolytic virus vaccine in advanced colorectal cancer by modulating T-cell activity.

The paper shows RSK2 compensates for MLCK loss in smooth muscle contractility through a novel signaling pathway involving PDK1 and Erk1/2.

This study shows that deamidation of ubiquitin by bacterial enzymes creates salt bridges that disrupt its structure and dynamics, impairing ubiquitin signaling.

This study combines GVI and NDVI to analyze urban street greening in Zhongshan City, finding strong correlation and scale sensitivity, and proposes optimization strategies.

This study identifies TOL-1 as a ligand for LAT-1 in C. elegans, showing their interaction is essential for embryonic development.

This study uses a deep learning algorithm to discover highly divergent RNA viruses in metatranscriptomes, identifying 161,979 potential species and 180 supergroups.

This study investigates the mechanisms of action and resistance of anti-PD-1+LAG-3 and anti-PD-1+CTLA-4 combinations in melanoma models, finding differential effects on CD4+ T cell polarization and CD8+ T cell function.

This study identifies associations between tumor microbiomes and host molecular aberrations across 32 cancer types using multi-omics data from TCGA.

This study shows RBP-J regulates blood Ly6Clo monocytes and their derived lung macrophages by controlling CCR2 expression.