J. Ma

This study shows that MG53 reduces neuromuscular junction loss and extends survival in ALS by protecting diaphragm muscle and NMJ integrity.

This paper describes an interactive museum exhibit that synchronizes live human cardiomyocytes to visitor heart rates, engaging the public with heart biology and stem cell science.

This study shows that intestinal helminth infection alters CD4+ T cell composition in the skin, leading to long-term changes in immune responses to antigens.

This study investigates salt-induced structural transitions in the DNA-interacting protein SSB using magnetic tweezers and infrared spectroscopy, revealing discontinuous thermodynamic behavior at binding mode transitions.

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

The paper investigates the immunogenicity of a public neoantigen derived from mutated PIK3CA, showing it is recognized by T cells and presents a framework for immunotherapy.

This study develops polypeptide-based inhibitors that target conserved regions of viral glycoproteins, effectively reducing expression across multiple virus strains with low sequence identity.

The paper shows that mice with a diverse wild microbiota develop stronger allergic inflammation compared to those without microbial exposure.

This study reveals a kinetic rheostat mechanism in the Arabidopsis thiamine pyrophosphate riboswitch through ensemble switching dynamics involving TPP and Mg2+ interactions.

This study investigates how deafness-associated DIAPH1 mutations affect autoinhibition and actin assembly, finding variable disruption of autoinhibition among mutants.

This study links nonsterile immunity to cryptosporidiosis in infants with mucosal IgA against Cp23 and reduced growth faltering.

The paper investigates the relationship between NDRG1 expression, DNA methylation, and DNMT family in gastric cancer, finding DNMT1 correlates with prognosis.

This study develops and evaluates two multi-epitope vaccines against H. pylori using computer-aided design, showing they reduce bacterial colonization and stomach damage in infected mice.

This study develops a multi-epitope chimeric antigen (MECU) that generates a broadly reactive antibody response against H. pylori and reduces stomach colonization in mice.

The paper identifies and evaluates strong constitutive promoters in Listeria monocytogenes to enhance foreign antigen expression, finding P18 as the most effective.

The paper compares transcriptomic profiles of different human trophoblast development models to identify differentially expressed genes and transcription factors.

This study shows that sublingual immunotherapy with recombinant dog allergens reduces airway hyperresponsiveness and type 2 inflammation in a mouse model of dog allergy.

This study examines splenomegaly, histopathology, and splenocyte composition in mice infected with Plasmodium berghei K173, showing strain-specific differences in parasite control and splenic function.

This study shows that Matriptase promotes tissue damage responses by activating Gq signaling, leading to RSK and DUOX activation, which disrupts epithelial junctions and contributes to inflammation and carcinoma.

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

This study investigates the tumor-suppressing functions of hsa-miR-654-5p in lung cancer through bioinformatic analysis and in vitro experiments, revealing its role in inhibiting EMT, proliferation, and migration.

This paper develops a subunit vaccine against SARS-CoV-2 that induces sterilizing immunity in hamsters, with high neutralizing antibody titers and protection against infection and symptoms.

The paper develops a method to measure subnanometer position changes of biomolecules in live cell plasma membranes using extracellular quenchers and validates it by studying peptide-induced membrane perforation.

The paper shows that centromere drive is suppressed by two parallel pathways, with heterochromatin and kinetochore pathways differing in their suppression of selfish DNA effects.

This paper identifies and characterizes a potent human monoclonal antibody, HB27, that blocks SARS-CoV-2 receptor binding and membrane fusion, showing protective effects in mice and non-adverse effects in rhesus macaques.

This study develops and tests bat influenza-based live attenuated vaccines for pigs, showing they reduce viral replication and lesions without causing vaccine-associated enhanced respiratory disease.

The paper models how signal inactivation sharpens and stabilizes chemical signal propagation through the cytosol by filtering non-geodesic paths in human B cells.

This study characterizes urine metabolomics across the lifespan in healthy individuals, identifying age- and gender-specific metabolic patterns and pathway enrichments.

This study identifies capsule switch in Streptococcus suis strains through comparative genomic analyses, revealing genetic exchange between SS2, SS3, and SS7 strains.

This study investigates how light intensity affects the coloration and structure of chimeric leaves in Ananas comosus var. bracteatus, finding that 50% shade optimizes growth and ornamental value.