J. Ma

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

This study identifies a new orthonairovirus, SGLV, associated with human febrile illness in northeastern China, showing its presence in ticks and clinical symptoms in infected patients.

This study shows that MSR1 restricts Chikungunya virus infection by activating autophagy through interactions with ATG12 and the ATG5-ATG12-ATG16L1 complex.

This paper introduces a method to measure bacterial surface charge density using second harmonic light scattering and finds that Gram-negative bacteria have seven times higher negative charge density than Gram-positive bacteria.

This paper develops a robust neutralization assay using SARS-CoV-2 S-bearing VSV pseudovirus and ACE2-overexpressed BHK21 cells to screen antibodies and quantify neutralizing titers.

The paper determines the Cryo-EM structures of S-Trimer variants for COVID-19 vaccine development, showing they adopt a tightly closed conformation similar to the full-length S protein.

The paper determines the cryo-EM structure of MgtE in Mg2+-free conditions, revealing cytoplasmic pore opening and kink motions in TM2 and TM5 helices.

This study shows that SARS-CoV-2 spike protein subunit vaccines induce strong neutralizing antibodies in mice and macaques, with high titers after a single dose or dose-sparing regimen.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This study identifies Na2CO3-responsive proteins and phosphoproteins in alkaligrass, revealing mechanisms for photosynthesis and ROS homeostasis under alkali-salinity stress.

This paper improves an adenine base editor for in vivo use, achieving efficient dystrophin restoration in dystrophic mice with minimal off-target effects.

This study evaluates 1403 FDA-approved drugs for SARS-CoV-2 inhibition using pseudovirus and authentic virus assays, identifying four compounds with potent effects and a synergistic combination.

This study shows that STAT2 signaling both restricts SARS-CoV-2 spread and causes severe pneumonia in infected hamsters.

The paper analyzes the Human Protein Atlas database to identify potential key molecules in the airway epithelial cell microenvironment that may facilitate SARS-CoV-2 entry and immune response activation.

This study shows that recombinant human MG53 protein protects cardiomyocytes from ischemia-reperfusion-induced oxidative stress by preserving mitochondrial integrity.

The rab8d-dependent plastid signal mediated by ATM and GUN1 regulates the root meristem size and renewal of root stem cells, respectively.

This study uses ultrafiltration to separate extracellular vesicles from MSC secretome, showing EVs and non-EV components both contribute to tissue regeneration in vivo.

This study translates dog-to-human aging by identifying conserved epigenetic changes, showing methylation patterns align physiological milestones across species.

This paper introduces cancer avatar models using genetically engineered hiPSCs to study tumor development and heterogeneity in glioblastoma.

This study evaluates a hyperspectral model for estimating aboveground biomass in Khorchin grassland using field and TM8 data, finding an exponential relationship with R2 = 0.636.

This study develops a computational framework to predict cancer progression using mutator phenotypes derived from tumor phylogenies, showing improved predictive power over traditional clinical and driver-centric features.

This study evaluates how different storage conditions, preservation periods, and sequencing platforms affect gut microbiome profiles using 16S rRNA gene sequencing.

This study predicts a high risk of the fall armyworm invading Japan and the Korean Peninsula via migration based on trajectory analysis and meteorological data.

The paper uses cryo-EM to study SOPA1's structure and conformational changes upon GTP binding, revealing its unique mechanism in mitochondrial membrane fusion.

The paper predicts migratory routes of the fall armyworm in eastern China using trajectory simulation combined with flight behavior and meteorological data, identifying two pathways to corn-producing regions.

This study identifies TRIM21-SERPINB5 as a mechanism promoting radioresistance in nasopharyngeal carcinoma by repressing TP53 through GMPS degradation.

This study evaluates if DNA-based methods can effectively understand microbial community structure and function in sludge by comparing total and active communities using DNA and RNA sequencing.

This study identifies and validates a novel QTL on chromosome 6HL in barley that confers resistance to Fusarium crown rot, explaining 29.1% of phenotypic variance.

This study identifies two regions on MiD51 that bind Drp1 and shows that MiD51 dimerization via a disulfide bond is required for Drp1 recruitment, revealing a multi-faceted regulatory mechanism for mitochondrial fission.

This paper classifies lung adenocarcinomas into six subtypes based on EGFR, KRAS, and TP53 mutations, finding associations with prognosis and validating the classification against clinical outcomes.