J. Yang

This paper uses topological data analysis to create a topological representation of gene expression across flowering plants, revealing conserved expression patterns linked to tissues and stress responses.

The paper identifies enhancer-based biomarkers of resistance to anti-PD-1 therapy in melanoma and suggests enhancer blockade combined with ICB as a potential strategy to improve treatment responses.

The paper investigates how female mice's reproductive state changes their response to male urinary pheromones, showing preference in estrus and avoidance in late pregnancy.

The paper investigates how plasma membrane nanodeformations influence actin polymerization and type II IFN signaling via CIP4/CDC42 recruitment.

This paper reports cryo-EM structures of the IgM BCR and its Fab-deleted form, revealing an asymmetric arrangement and novel structural principles of BCR assembly.

The paper identifies native peptide substrates for bacterial Hsp70 DnaK, finding conserved and divergent binding properties among them, with VP5 showing potential as an antibacterial lead.

This paper engineers a precise adenine base editor, ABE9, with reduced bystander mutations and off-target effects, enabling efficient and accurate A-to-G editing in mouse and rat embryos.

This study shows macrophages can migrate across non-adhesive PEG surfaces by adopting a mesenchymal mode, overcoming the limitations seen in other cell types.

This study identifies spike-specific CXCR3+ TFH cells as key drivers of long-term antibody responses in SARS-CoV-2 infection and vaccination.

The paper identifies TRIM32 as a host E3 ubiquitin ligase that targets SseK3, an SPI-2 effector, to restrict Salmonella-induced filament biogenesis and replication.

The paper reports cryo-EM structures of FSHR in inactive and active states, revealing a conserved activation mechanism and the role of H6157.42 in agonist selectivity.

The paper characterizes the genomic and transcriptomic landscape of MDA PCa PDX models and develops an organoid platform to study prostate cancer heterogeneity and resistance.

This study shows that asparagine restriction induces a biphasic response in CD8 T cells, enhancing their metabolic fitness and antitumoral function through ATF4/NRF2-dependent mechanisms.

The paper investigates how phase separation of N-myc affects gene transcription and finds that only a small fraction of N-myc-regulated genes are influenced by this process.

This study directly observes bacterial spreading in soil-like conditions, showing surfactant-producing bacteria generate corner flows that influence their movement and bioremediation potential.

This paper determines the crystal structure of DOCK10DHR2, revealing its dual specificity for CDC42 and RAC, and a unique 2:1 stoichiometry in complex with RAC.

This study identifies CFAP418's role in lipid binding and membrane processes, showing that its disruption causes lipid imbalance and mitochondrial defects in retinal degenerations.

This study develops a method to fluorescently label Tau protein at its C-terminus to avoid disrupting its microtubule-binding region, showing no significant effect on its aggregation properties.

This study shows that SMAD4 suppresses colitis-associated colon cancer by inhibiting CCL20/CCR6-mediated inflammation in mice.

This study develops modRNA-based CRISPR systems for efficient genome editing in human pluripotent stem cells, achieving higher knockout efficiency than plasmid-based methods.

This study identifies genomic adaptations in Leuciscus waleckii to extreme alkaline environments through genome assembly and population analysis.

This study develops a stable and safe mRNA vaccine (cmRNA-1130) using degradable lipid nanoparticles against the SARS-CoV-2 Delta variant, showing potent immune responses and stability.

This paper introduces PathFinder, an interpretable AI framework for discovering new tissue biomarkers in liver cancer, identifying tumor necrosis as a prognostic factor.

This study evaluates antimicrobial susceptibility of NTM clinical isolates from Shanghai using the MYCO test system and MIC distributions of 8 drugs, finding BDQ and CFZ show efficient in vitro activity.

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

This paper demonstrates a motion correction algorithm, ResyncCT, that improves estimates of left ventricular mechanical activation times from 4DCT images, potentially reclassifying 96% of patients for CRT response.

This study shows that exosomal miR23a from rickettsial-infected endothelial cells disrupts BMEC barrier function by targeting ZO-1, and that anti-miR23a exosomes can restore barrier integrity.

This study evaluates how transfer learning, phylogenetic distance, and sample size affect bioacoustic data automation accuracy across ten bird species.

This paper introduces an argonaute-facilitated PCR platform that improves PCR sensitivity by using MejAgo to enhance guide DNA/template pairing, eliminating the need for an annealing step.