J. Yang

This study uses single-cell RNA sequencing to identify novel subtypes and intratumoral heterogeneity in olfactory neuroblastoma.

This study shows SOS2 modulates EGFR-PI3K signaling threshold, affecting osimertinib efficacy and resistance in lung adenocarcinoma.

This study uses comparative transcriptomics across mammals to show that longevity is influenced by polygenic and indirect selection, with key pathways like insulin signaling showing correlations with lifespan.

This study identifies VRAC as an ATP-releasing channel in microglia contributing to neuropathic pain and shows dicumarol inhibits it, reducing pain behaviors in mice.

This study develops TAG72-CAR T cells with antigen-dependent IL-12 signaling to enhance anti-tumor activity and systemic disease targeting in ovarian cancer.

This paper presents a high-resolution cryo-EM structure of TMEM87A, revealing its unique architecture and mechanisms of ion conduction and gating in the Golgi apparatus.

This paper develops a 3D SCLC co-culture organoid model to study chemotherapy resistance and fibroblast interactions in relapsed SCLC.

The paper identifies chloride as an allosteric activator and inhibitor of Class-D beta-lactamases, revealing its dual role in enzyme kinetics and suggesting new antibiotic strategies.

The paper determines the cryo-EM structure of the complete inner kinetochore of budding yeast, revealing its architecture and DNA interactions.

The paper examines how latitude affects ecosystem stability in forests across different spatial scales, finding that species asynchrony and stability play key roles, with latitude influencing these mechanisms to counteract species richness effects.

This paper introduces a method to quantitatively map the local quality of super-resolution microscopy images, enabling better integration of reconstructions and detection of uncertainties.

This study reports chromosome-level genome sequences of two Leonurus species, providing resources for studying bioactive molecules in medicinal plants.

This study develops two quadrivalent mRNA vaccines against monkeypox virus and shows they induce antibodies, cellular immunity, and protection against Vaccinia virus in mice.

This study identifies age and sex differences in cardiac matrix-bound exosomes and shows their synergistic miRNA effects on fibrosis.

This study evaluates antibody kinetics and durability after CoronaVac vaccination in health subjects, finding waning antibody levels over time and improved responses with a booster dose.

This study shows IL-6 suppresses TFH cell responses in neonatal mice by enhancing IL-2 activity, while IL-6 deficiency improves vaccine responses.

This study shows that P. multocida infection increases respiratory epithelial permeability in mice and humans by activating the HIF-1 and VEGFA signaling pathways.

The paper creates a unified genetic marker dataset from maize resequencing data to enhance the analysis of genetic diversity and functional allele frequency changes.

This study shows that exposure to tire wear particle leachate across multiple generations impairs reproduction in rotifers, leading to population collapse.

The paper shows high Mtb burden in macrophages leads to cell death and cross-presentation of TB10.4 antigen to CD8 T-cells via the ESX-1 system, promoting immune response but potentially worsening immunopathology.

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

This paper introduces FD-DeepLoc, a deep learning method for high-throughput 3D super-resolution imaging over a large field of view using a sCMOS camera.

This study investigates brevicidine's antimicrobial mechanism against AMR Gram-negative pathogens and shows its efficacy in a mouse model.

This study identifies two progenitors of sweetpotato using horizontal transferred T-DNA and haplotype-based phylogenetic analysis, revealing its origin from a reciprocal cross and whole genome duplication.

This study uses transcriptomic analysis to examine gene expression changes in cigar leaves at different growth stages, identifying key pathways and regulatory networks associated with maturity.

This study reveals polyphyletic origins of clerodane diterpene biosynthesis in Lamiaceae by analyzing genomes and metabolic pathways of three species.

This study sequenced the genome of water wisteria, revealing genes and pathways involved in its environmental adaptation and leaf shape changes.

This study shows neonatal CD19+CD43- B cells produce IL-10 via STAT5-mediated IL-6 secretion upon BCR activation, revealing a novel mechanism for IL-10 production in neonates.

This study determines the cryo-EM structure of SLC19A1 and identifies key residues and coupled substrates for folate recognition.

The paper investigates the dynamics and function of Munc18-mediated SNARE template complexes using optical tweezers, revealing a dynamic conformational transition that facilitates specific SNAP-25 binding.