J. Zhang

The paper shows that EZH1 and EZH2, two catalytic subunits of PRC2, are differentially activated to regulate H3K27 methylation, with AEBP2 adding additional stimulation.

This study identifies sexual lineage-specific DNA methylation in Arabidopsis that regulates meiosis by controlling gene expression through RNA-directed DNA methylation.

This study characterizes the molecular landscape of pediatric AML, identifying age-specific mutations and fusion oncoproteins that differ from adult AML.

The paper identifies 5hmC signatures in cfDNA as accurate biomarkers for detecting colorectal and gastric cancers, outperforming conventional markers and matching tissue biopsy results.

This study identifies AtERG2, a mitochondrial GTPase in Arabidopsis, as essential for early embryo development, with mutants showing seed abortion and ROS accumulation.

This study identifies ERF19 as a negative regulator of PTI in Arabidopsis, showing that NINJA represses ERF19 to fine-tune immune responses against pathogens.

This study shows mechanical compaction of mesenchyme drives tissue folding in vitro through ECM strain and collagen alignment, without genetic engineering.

This study shows that extrachromosomal DNA elements and chromosomal alterations in glioblastoma have distinct inheritance patterns and contribute to genomic heterogeneity during tumor evolution.

This study shows that GPER activation inhibits melanoma growth and enhances response to PD-1 blockade by promoting differentiation and reducing immune suppressive proteins.

This study identifies senkyunolide A as a neuroprotective compound that mitigates corticosterone-induced cell apoptosis by modulating PP2A and α-synuclein levels in PC12 cells.

This study shows that sepsis during surgery increases metastases in mice, while hemorrhagic shock and hypothermia do not.

This study investigates whether sirtuin-mediated acetylation regulates 2-HG production by metabolic enzymes, finding no direct link between enzyme acetylation and 2-HG generation.

The paper predicts fluoroquinolone susceptibility in K. pneumoniae using whole genome sequence data and protein abundance measurements from liquid chromatography-tandem mass spectrometry.

This paper identifies Minion, a microprotein essential for muscle cell fusion and development, and shows it works with Myomaker to induce cell fusion in mammals.

The paper investigates gene expression variations in yeast and finds most are neutral, not adaptive, suggesting random mutations drive expression evolution.

The paper tests the neutral hypothesis of phenotypic evolution by analyzing morphological and gene expression traits in yeast, finding adaptive evolution in morphology but not in gene expression.

This study shows that deleting the Myc super-enhancer region in mice reduces Myc expression and tumor susceptibility without overt phenotypes, suggesting therapeutic potential for targeting this element in cancer.