J. Zhang

The paper describes the structure of a chimpanzee SIV Env trimer and shows it induces HIV V2-specific neutralizing antibodies in mice.

The paper shows that H1 depletion in Arabidopsis thaliana vegetative cells allows DNA demethylation and transposon activation through DEMETER access.

This study identifies small molecules that modulate alternative splicing by targeting RNA G-quadruplexes through a high-throughput screen.

This study shows that DSBA protects bone marrow cells from radiation toxicity by activating Nrf2 and stress response genes in mice.

This study identifies a β-carotene-binding protein that regulates body color transition in locusts by modulating red pigment accumulation.

The paper develops a biophysical method to quantify chromatin compaction dynamics during DNA damage response using FLIM-FRET microscopy and identifies roles of ATM and RNF8 in chromatin reorganization.

The paper develops IPTG-controlled conditional suicide plasmids for efficient and regulatable transposon mutagenesis in multiple bacterial species.

This study shows that FADD is critical for intestinal intraepithelial lymphocyte (IEL) development, particularly affecting CD8αα+ TCRγδ+ T cells, and its loss worsens colitis.

This study shows UPF1 associates with nascent RNAs in the nucleus and is required for mRNA release from transcription sites in Drosophila.

This study shows that an early nitric oxide burst mediated by nitric oxide synthase in ammonium-supplied rice roots reduces drought-induced oxidative damage by enhancing antioxidant defenses.

The paper shows that ATRX mutations and MYCN amplification are mutually exclusive in neuroblastoma and lead to synthetic lethality.

This study identifies DEK5 as a homolog of bacterial TamB required for chloroplast envelope biogenesis and metabolite transport in maize.

The paper identifies microRNA-dependent regulation of biomechanical genes that maintain tissue stiffness homeostasis through cytoskeletal and extracellular matrix control.

This study shows that gut segments, not diet, are the main factor shaping the intestinal microbiome in grass carp, with diet having a smaller impact in distal gut regions.

The paper investigates the two-step binding kinetics of tRNAGly by the glyQS T-box riboswitch and identifies structural elements that regulate each step.

This study generates transgenic pigs expressing microbial enzymes to enhance feed digestion and reduce nutrient emissions, showing improved growth and lower environmental impact.

This study isolates and characterizes Bacillus amyloliquefaciens subsp. plantarum XH-9, showing it promotes plant growth and suppresses Fusarium oxysporum in wheat.

This study characterizes the structure, function, and dynamics of the gamete fusogen HAP2, revealing dynamic regions and structural features critical for fusion.

This study identifies extracellular HBV RNAs as heterogeneous in length, present in virions and capsid-antibody-complexes in CHB patients, and capable of serving as templates for viral DNA synthesis.

The paper identifies BED-domain containing immune receptors in wheat that confer diverse resistance to yellow rust, highlighting their potential for broad-spectrum resistance breeding.

This study shows myricetin reduces inflammation in LPS-induced RAW 264.7 macrophages and mouse models of acute lung injury by inhibiting NF-κB and MAPK pathways.

This study identifies EZH2 as a p53 mRNA-binding protein that enhances translation of gain-of-function p53 mutants, promoting cancer growth and metastasis, and shows that inhibiting EZH2 causes synthetic lethality in these cells.

The paper reports the near-atomic structure of the polycystin 2-l1 ion channel at 3.1 Å resolution, revealing structural differences from polycystin-2 that correlate with distinct ion permeability.

This study identifies miR-452-5p as a key regulator of renal cancer metastasis, showing its upregulation and role in promoting invasion through SMAD4/SMAD7/EMT signaling.

This study presents the cryo-EM structure of the mouse TRPC4 ion channel, revealing unique features that contribute to its ion selectivity and evolutionary diversity within the TRP family.

This study shows metformin improves uterine progesterone signaling in PCOS-like rats by reducing PGR and ER expression and correcting gene expression abnormalities.

This study shows that in situ administration of cytokine combinations can induce complete tumor regression in mice, including large tumors, through strong synergistic effects and systemic antitumor immunity.

The paper analyzes population genomic data of two dolphin species to show contrasting demographic changes during the last glacial period.

This study investigates how the bacterial sRNA SgrS prioritizes and regulates its target mRNAs, revealing that regulatory hierarchy depends on binding site number, position, and cofactors like Hfq.