Author

K. G. C. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

G. Dougan· 2 shared P. A. Lyons· 2 shared Z. Zhang· 2 shared A. Alazami· 1 shared A. Alloatti· 1 shared A. Bateman· 1 shared A. Bonaud· 1 shared A. C. Morris· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

G. Dougan

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Author profile →

5 papers

Recent·Most cited

Fate-mapping lymphocyte clones and their progenies from induced antigen-signals identifies temporospatial behaviours of T cells mediating tolerance

M. Takahashi, T. So, K. Williamson, Z. Hosseini, K. Kania, M. Ruhle, T. Mann, M. J. Schujis, P. Coupland, D. Naisbitt, T. Y. F. Halim, P. A. Lyons, P. Lio, K. Okkenhaug, D. J. Adams, , J. E. D. Thaventhiran

This study introduces a novel fate-mapping mouse to track lymphocyte clones and their progenies in response to antigen signals, revealing distinct T cell behaviors in tumor immunity.

bioRxiv · Mar 16, 2023Immunology

Obesity associated with attenuated tissue immune cell responses in COVID-19

S. A. Guo, G. S. Bowyer, J. R. Ferdinand, M. Maes, Z. K. Tuong, E. Gilman, M. Liao, R. G. H. Lindeboom, M. Yoshida, K. Worlock, H. Gopee, E. Stephenson, P. A. Lyons, K. G. C. Smith, M. Haniffa, , M. R. Clatworthy

The paper finds that obesity is associated with reduced immune and inflammatory responses in COVID-19 patients, including lower expression of IFN and IFNγ response genes in lung and blood cells.

bioRxiv · Jan 14, 2022 · PreprintImmunology

Plasma cell maintenance and antibody secretion are under the control of Sec22b-mediated regulation of organelle dynamics

A. Bonaud, L. Gargowitsch, S. Gilbert, E. Rajan, P. Canales-Herrerias, D. Stockholm, N. Rahman, M. Collins, D. L. Hill, A. Alloatti, N. Alouche, S. Balor, V. Soldan, D. Gillet, J. Barbier, , M. Espeli

This study identifies Sec22b as a critical regulator of plasma cell maintenance and function by controlling organelle dynamics, leading to reduced antibody secretion and impaired immune response.

bioRxiv · Jan 14, 2022 · PreprintImmunology

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

L. O. Randzavola, P. M. Mortimer, E. C. Garside, E. R. Dufficy, A. Schejtman, G. Roumelioti, L. Yu, M. Pardo, K. Spirohn, C. Tolley, C. Brandt, K. Harcourt, E. Nichols, M. Nahorski, G. Woods, , D. C. Thomas

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

bioRxiv · Sep 14, 2021Immunology

Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance

Z. Zhang, F. Gothe, P. Pennamen, J. James, D. MacDonald, C. P. Mata, Y. Modis, M. Acres, W. Haller, C. Bowen, R. Doffinger, J. Sinclair, S. Brothers, A. Alazami, Y. Zhang, , M. J. Lenardo

This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.

bioRxiv · Nov 26, 2018Immunology