Author

L. A. Chakrabarti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

R. Robinot· 4 shared S. Gellenoncourt· 3 shared M. Vignuzzi· 2 shared N. Liu· 2 shared O. Schwartz· 2 shared A. Grauslys· 1 shared A. J. Samelson· 1 shared A. Mac Kain· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersMicrobiology

R. Robinot

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The spike-stabilizing D614G mutation interacts with S1/S2 cleavage site mutations to promote the infectious potential of SARS-CoV-2 variants

S. Gellenoncourt, N. Saunders, R. Robinot, L. Auguste, M. M. Rajah, J. Kervevan, R. Jeger-Madiot, I. Staropoli, C. Planchais, H. Mouquet, J. Buchrieser, O. Schwartz, L. A. Chakrabarti

This study shows the D614G mutation enhances the infectious potential of SARS-CoV-2 variants by synergizing with cleavage site mutations like P681H/R to increase spike fusogenicity.

bioRxiv · May 20, 2022Microbiology

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

B. Zhou, R. Zhou, J. F.-W. Chan, J. Zeng, Q. Zhang, S. Yuan, L. Liu, R. Robinot, S. Shan, J. Ge, H. Y.-H. Kwong, D. Zhou, H. Xu, C. C.-S. Chan, V. K.-M. Poon, , Z. Chen

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

bioRxiv · Oct 5, 2021 · PreprintMicrobiology

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2

A. J. Samelson, Q. D. Tran, R. Robinot, L. Carrau, V. V. Rezelj, A. Mac Kain, M. Chen, G. N. Ramadoss, X. Guo, S. A. Lim, I. Lui, J. Nunez, S. J. Rockwood, J. Wang, N. Liu, , M. Kampmann

This study identifies BRD2 as a regulator of ACE2 transcription and shows that BRD2 inhibitors block SARS-CoV-2 infection in human cells and animal models.

bioRxiv · Jan 19, 2021Cell Biology

SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance

R. Robinot, M. Hubert, G. Dias de Melo, F. Lazarini, T. Bruel, N. Smith, S. Levallois, F. Larrous, J. Fernandes, S. Gellenoncourt, S. Rigaud, O. Gorgette, C. Thouvenot, C. Trebeau, G. Dumenil, , L. A. Chakrabarti

This study shows SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance, potentially facilitating viral spread to the deeper lung.

bioRxiv · Oct 6, 2020 · PreprintMicrobiology

Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential

B. Meyer, J. Chiaravalli, S. Gellenoncourt, P. Brownridge, D. P. Bryne, L. A. Daly, A. Grauslys, M. Walter, F. Agou, L. A. Chakrabarti, C. S. Craik, C. E. Eyers, P. A. Eyers, Y. Gambin, A. R. Jones, , E. Emmott

This study identifies novel SARS-CoV-2 protease cleavage sites and cellular targets using mass spectrometry, showing that targeting these proteins can inhibit viral replication.

bioRxiv · Sep 16, 2020Microbiology