L. Zhang

This study shows that high glucose levels increase the effectiveness of chemotherapy in pancreatic cancer by reducing glutathione biosynthesis, which enhances oxidative stress in cancer cells.

This study evaluates a multivalent mRNA vaccine encoding SARS-CoV-2 and SARS-CoV receptor-binding domains, showing it induces cross-neutralizing antibodies against multiple variants in mice.

The paper reports rearing records of arthropods from over 527,000 oak galls, identifying 151,075 animals and providing ecological and phylogenetic insights into gall-associated taxa.

The paper identifies nanobodies with broad neutralizing activity against multiple sarbecoviruses and shows their protective efficacy in a mouse model.

The paper examines soil water consumption in rain-fed apple orchards and wheat fields to assess the impact of land use change on water stress and soil desiccation.

This study develops an oral rhabdoviral vaccine that boosts SARS-CoV-2 immunity in nonhuman primates by enhancing viral tropism through G protein trans-complementation.

This study shows that inducing the bacteriophage PinR in DNA repair-deficient E. coli promotes antibiotic resistance evolution by repressing antioxidative genes and causing ROS bursts.

This study uses natural variation in Arabidopsis to identify 25 genes affecting water use efficiency through GWAS and reverse genetics, revealing diverse biological processes involved in WUE.

This study shows that TSS inhibits the TLR3 pathway, reducing CVB3 infection severity in mice and cell cultures.

This study characterizes prefusion-F-specific antibodies from elderly individuals naturally infected with hMPV, revealing their epitope recognition and neutralizing activity.

This study identifies oxidative phosphorylation pathway disruption as an alternative mechanism causing Diamond-Blackfan anemia and shows coenzyme Q10 can rescue erythroid defects.

The paper uses in vivo CRISPR screens to identify Serpinb9 and Adam2 as genes regulating immune therapy response in lung cancer, showing their roles in immune suppression and enhancement.

This study identifies metabolic vulnerabilities in DIPG subtypes and shows that targeting these vulnerabilities with specific drugs can extend survival in preclinical models.

A comparative transcriptome and DNA methylome analysis of inflorescence between upland and lowland ecotypes reveals gene expression and DNA methylation variation underlying inflorescence divergence in Panicum hallii.

This study identifies a flowering time QTL in Panicum hallii that shows gene-by-environment interaction affecting fitness, with coastal allele advantage only in its local habitat.

The paper shows that auxin and ERECTA family genes are both required for leaf initiation, with PINOID playing roles beyond auxin distribution.

This study investigates the redifferentiation process in adult mouse hearts after dedifferentiation, finding residual dedifferentiation signatures and protective effects against ischemic injury.

This study shows that phosphorylation of DSB-1 by PP4PPH-4.1 and ATRATL-1 regulates meiotic DSB levels in C. elegans, with DSB-2 compensating for age-related inactivation of DSB-1.

The paper identifies Mebendazole as a small molecule that increases lateral root angle in Arabidopsis by inhibiting CTR1 kinase and activating ethylene signaling.

This study develops two ERR agonists that improve heart failure by enhancing fatty acid metabolism and mitochondrial function in mice.

This study identifies stage-specific microbial and metabolic changes in RA progression using multi-omics data from a cohort of patients.

This study investigates host shifts in Nearctic oak gall wasps and finds frequent shifts between host plants and organs, suggesting host shifts drive speciation in this group.

This study shows that chronic intermittent hypobaric hypoxia prevents contrast-induced acute kidney injury in rats by activating the HIF-1/BNIP3 pathway to enhance antioxidant capacity and mitochondrial autophagy.

This paper identifies a SARS-CoV-2 neutralizing antibody, ABP-310, that is effective against multiple variants including Omicron and SARS-CoV, suggesting broad therapeutic potential.

This study compares Reelin+ HSCs and Desmin+ HSCs in liver fibrosis using fate tracing, showing differences in activation, migration, and proliferation in response to cholestatic and hepatotoxic injuries.

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

This study uses single-nuclei transcriptomics to analyze dog hippocampus cell types and identifies convergence between differentially expressed genes and putative positively selected genes related to nervous system development.

This study compares the transcriptional responses of two nematodes to different diets, finding diet-specific effects on development and lifespan.

The paper identifies a DNA uptake mechanism in cell wall-deficient bacteria that resembles eukaryotic endocytosis and may represent an ancient process for macromolecule acquisition.