L. Zhang

The paper identifies type IV pili as a critical virulence factor in Paenibacillus thiaminolyticus clinical isolates associated with postinfectious hydrocephalus.

This paper evaluates click chemistry-based methods for cross-linking peptide enrichment, finding that acid-cleavable protein-based conjugation identifies the most cross-linked peptides.

This paper introduces SPACX, a method to profile protein conformation and interactions in living cells, revealing subcellular-specific heterogeneity and functional differences in PTEN.

This study uses imaging mass cytometry to analyze tumor-immune microenvironments in melanoma patients, identifying distinct microenvironment archetypes linked to responses to anti-PD-1 therapy.

The paper analyzes the distribution of virulence factors in Bacillus cereus strains using phylogenetic and protein prediction methods, revealing clustering based on virulence genes and structural features.

This study identifies KLK10 as a flow-sensitive endothelial protein that inhibits inflammation and atherosclerosis through a PAR1/2-dependent mechanism involving HTRA1 regulation.

This study identifies FAM84B amplification as a marker of poor prognosis in ESCC and shows it promotes cell proliferation by interacting with NPM1 to suppress CDKN2A.

This study reports the crystal structure of the Omicron SARS-CoV-2 RBD-ACE2 complex and identifies key mutations enhancing ACE2 binding and immune escape.

The paper examines how ecology and geography influence habitat and sexual isolation in closely related gall-forming wasp species, finding that sympatric species with different host plants show the strongest isolation.

The paper tracks cyanopeptides and their impact on microbiota during a CyanoHAB, finding that cyanopeptide restriction and degradation drive community assembly.

This study identifies THEMIS as a substrate of SHP1 and shows it has phosphorylation-dependent and -independent roles in T cell development.

This study shows an engineered ACE2 peptide effectively mitigates ARDS and death in mice infected with multiple SARS-CoV-2 variants.

This study identifies potent inhibitors targeting KRAS G12D via a salt-bridge interaction, showing efficacy in reducing tumor volume and synergizing with anti-PD-1 therapy.

This study profiles healthy human kidney cells from 19 donors to reveal sex-based transcriptional differences and tissue-specific immune features.

This study shows that a specific static magnetic field reduces oxidative stress and liver damage caused by alcohol consumption in mice.

The paper identifies LRRC15 as an inhibitory receptor that blocks SARS-CoV-2 spike-mediated entry in trans, primarily expressed in fibroblasts and not co-expressed with ACE2.

This study identifies circRNA expression patterns in healing and non-healing wounds and finds two circRNAs that impair keratinocyte migration while promoting proliferation in non-healing venous ulcers.

This study identifies genes involved in salinity adaptation in the marine nematode Litoditis marina through transcriptomic and proteomic analysis of worms acclimated to different salinities.

This study shows NtrX regulates CtrA signaling network genes in S. meliloti, affecting cell division and linking nitrogen metabolism to cell cycle control.

This study develops an intranasal vaccine against SARS-CoV-2 using an influenza virus vector and shows it provides rapid, prolonged, and broad protection against multiple variants in hamsters.

The paper presents cryo-EM structures of yeast TRAPPII complex in apo and Ypt32-bound states, revealing its assembly mechanism and specific activation of Ypt31/Ypt32.

This study identifies PHGDH as essential for germinal center formation and shows its inhibition reduces lymphoma progression and improves survival.

This study identifies miR-144 as a regulator of adipogenesis by mediating the formation of the C/EBPα-FoxO1 protein complex, which influences AdipoQ expression and adipocyte differentiation.

The paper combines a STING agonist and an IL-2 superkine to enhance cancer immunotherapy, showing efficacy against both MHC I-deficient and MHC I+ tumors.

PASTE enables efficient, programmable gene integration without DNA breaks, applicable for research, cell engineering, and gene therapy.

This study shows that influenza virus directly infects cardiomyocytes, causing heart dysfunction and fibrosis, challenging the prevailing model of indirect cardiotoxicity.

The study reveals that the parasitic wasp Ormyrus labotus, considered a generalist, is actually a complex of multiple specialized species, highlighting the limitations of morphological classification.

This study shows that total parenteral nutrition (TPN) causes glucose metabolism disorders by altering gut microbiota and its metabolites, as demonstrated through human and mouse models.

This study shows that endophilin's curvature-sensitive motif requires electrostatic guidance for synaptic vesicle recycling, and that altering this property can restore function in non-functional chimeras.