L. Zhang

This paper introduces a method to locate cellular contents during cryoFIB milling using secondary-electron imaging, demonstrating its feasibility across different instruments and conditions.

This study creates a human fetal cerebellar cell atlas to identify transitional progenitors linked to aggressive medulloblastoma subgroups and their oncogenic mechanisms.

The study identifies RBP45d as a key regulator of 5' splice site selection in Arabidopsis by binding to intronic U-rich elements and interacting with PRP39a.

This study develops a potent non-covalent inhibitor of SARS-CoV-2 3CLpro, showing effective antiviral activity in human cells and animal models.

The paper introduces deep-APQ, a proteome quantitation method using segmented MS/MS acquisition of a1 ions, showing improved coverage and accuracy in E. coli proteome analysis.

The paper shows cardiolipin regulates Complex II assembly and stability in macrophages, linking it to inflammatory metabolic reprogramming.

This paper develops a transparent active ECoG array using ZnO-TFTs for electrophysiological monitoring, enabling simultaneous optical and MRI-compatible brain signal recording.

This paper identifies FcγRIIB-mediated capture of antibody-coated bacteria by liver sinusoidal endothelial cells as a mechanism for superior vaccine efficacy.

The paper reports the cryo-EM structure of the RNF complex in Azotobacter vinelandii, revealing its role in transferring electrons from NADH to ferredoxin using the proton motive force.

This paper identifies phthiocerol dimycocerosate (PDIM) as essential for Mycobacterium tuberculosis antibiotic tolerance under nutrient starvation, suggesting PDIM synthesis as a target to enhance antibiotic efficacy.

This study identifies FOXP2 as an oncogene in prostate cancer that activates MET signaling, promoting tumorigenicity through both full-length and truncated forms.

This study examines genomic heterogeneity and stability in pancreatic cancer organoids using single-cell whole-genome sequencing and transcriptomic analysis.

This paper develops a long-circulating molecular brush to enhance aptamer stability and bioactivity in vivo.

This study investigates TANGO2 deficiency in iPSC-derived cardiomyocytes and fibroblasts, finding no defects in mitochondrial OXPHOS function under baseline or fasting conditions.

This study investigates rhubarb's effects on constipation-induced inflammation, gut microbiome, and metabolism in mice, showing improvements in cytokine balance, microbial diversity, and fatty acid metabolism.

This study shows Ralstonia solanacearum alters root development in Arabidopsis through auxin-dependent and independent mechanisms, including promoting xylem differentiation and root hair formation.

This study determines the cryo-EM structure of TMEM87A, revealing its domain arrangement and suggesting a role in membrane trafficking rather than ion channel or GPCR function.

This paper investigates the cellular uptake, trafficking, and antisense gene regulation mechanisms of bottlebrush polymer-conjugated oligonucleotides in cancer cells.

This study examines how seasonal hydrological changes affect the transition of antibiotic resistance genes between particle-attached and free-living lifestyles in a deep freshwater reservoir.

The paper identifies G42 as a lysosomal calcium mobilizer that inhibits autophagy and viral infections by alkalizing lysosomal pH and blocking autophagosome-lysosome fusion.

This study investigates the role of Esp in strengthening enterococcal biofilms under acidic conditions, showing that Esp unfolding and aggregation enhance biofilm stability.

This study shows that loss of DNMT3A causes obesity by disrupting adipogenesis and triggering inflammation in adipose tissue.

The paper identifies nalacin as an inhibitor of GH3 amido synthetase, which regulates auxin conjugation in plants, with potential applications in agriculture and research.

This study uses single-cell transcriptomics to analyze the visual and nervous system of the bobtail squid, revealing novel cell types and molecular mechanisms of convergent evolution in visual systems.

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

This study combines theory and experiments to show that cellular protrusions coil around round fibers but not elliptical ones, driven by membrane curvature and adhesion energies.

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

This study shows Botrytis cinerea accelerates tomato fruit ripening and cell wall disassembly to promote infection, dependent on pectin-degrading enzymes.

This study engineers macrophages to inducibly secrete TRAIL in response to the tumor microenvironment, showing improved anti-tumor effects and reduced side effects in preclinical models.