Author

M. K. Saito

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Bioengineering· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Niwa· 2 shared M. Osawa· 2 shared T. Nakahata· 2 shared A. Ikenaka· 1 shared A. Li· 1 shared C. Mori· 1 shared C.-Y. Lin· 1 shared D. Song· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

A. Niwa

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Retinoids rescue ceruloplasmin secretion and alleviate oxidative stress in Wilson's disease-specific hepatocytes

D. Song, G. Takahashi, Y.-W. Zheng, M. Matsuo-Takasaki, J. Li, M. Takami, Y. An, Y. Hemmi, N. Miharada, T. Fujioka, M. Noguchi, T. Nakajima, m. K. Saito, Y. Nakamura, T. Oda, , Y. Hayashi

This study uses patient-derived iPSCs to identify retinoids as potential therapeutics for Wilson's disease by rescuing ceruloplasmin secretion and reducing oxidative stress.

Human Molecular Genetics · Oct 28, 2022Peer-reviewedCell Biology

SMN promotes mitochondrial metabolic maturation during myogenesis by regulating the MYOD-miRNA axis.

A. Ikenaka, Y. Kitagawa, M. Yoshida, C.-Y. Lin, A. Niwa, T. Nakahata, M. K. Saito

This study shows SMN regulates mitochondrial metabolic maturation during myogenesis by controlling the MYOD-miRNA axis, with miR-1 and miR-206 supplementation restoring mitochondrial function in SMN-deficient cells.

bioRxiv · Feb 13, 2022Cell Biology

Prediction of broad chemical toxicities using induced pluripotent stem cells and gene networks by transfer learning from embryonic stem cell data

J. Yamane, T. Wada, H. Otsuki, K. Inomata, M. Suzuki, T. Hisaki, S. Sekine, H. Kouzuki, K. Kobayashi, H. Sone, J. K. Yamashita, M. Osawa, M. K. Saito, W. Fujibuchi

This paper predicts chemical toxicities using induced pluripotent stem cells and gene networks via transfer learning from embryonic stem cell data, achieving high accuracy across multiple toxicity categories.

bioRxiv · Nov 5, 2021 · PreprintPharmacology & Toxicology

Aberrant localization of CDC42 C-terminal variants to the Golgi apparatus drives pyrin inflammasome-dependent autoinflammation

M. Nishitani-Isa, K. Mukai, Y. Honda, H. Nihira, H. Shibata, T. Tanaka, K. Kodama, E. Hiejima, K. Izawa, Y. Kawasaki, M. Osawa, Y. Katata, S. Onodera, T. Watanabe, S. Kure, , T. Yasumi

This study identifies that CDC42 C-terminal variants cause aberrant Golgi localization, leading to pyrin inflammasome activation and autoinflammation.

bioRxiv · Sep 3, 2021Immunology

Biomimetic Aorta-Gonad-Mesonephros on-a-Chip to Study Human Developmental Hematopoiesis

R. Sugimura, R. Ohta, C. Mori, A. Li, T. Mano, E. Sano, K. Kosugi, T. Nakahata, A. Niwa, M. K. Saito, Y.-s. Torisawa

The paper develops a microfluidic AGM-on-a-chip to study human developmental hematopoiesis and demonstrates its ability to induce endothelial-to-hematopoietic transition.

bioRxiv · Dec 23, 2019Bioengineering