M. Li

This study compares IgG antibody responses to BNT162b2 and mRNA-1273 vaccines, finding higher and earlier titers with mRNA-1273, possibly due to higher S-protein dosage.

This study demonstrates a T4 phage-based vaccine platform that incorporates M2e antigens, showing high immunogenicity and complete protection against influenza without adjuvants.

The paper uses in vivo cellular-level imaging to phenotype tumor-immune microenvironments, identifying distinct inflammation and endothelial anergy signatures linked to immunotherapy response.

The paper resurrects an ancient RuBisCO enzyme to test if uniform carbon isotope signatures are consistent across geological time, finding support for uniformitarian assumptions with caveats.

This study shows that Rho kinase regulates neutrophil NET formation, which contributes to UVB-induced skin inflammation.

The paper investigates the role of H3K27me3 and H3K9me3 histone modifications in the fungus Podospora anserina, showing their distinct functions in development and gene silencing.

The paper tests hypotheses about stomatal size-density scaling in plants using macroevolutionary models and phylogenetic regression on 2408 species, finding support for the stomatal-area increase hypothesis for higher gmax.

This study investigates how CO2 and RuBisCO concentration affect cyanobacterial growth and carbon isotope fractionation by engineering a RuBisCO-overexpressing mutant strain.

This study shows that intestinal helminth infection alters CD4+ T cell composition in the skin, leading to long-term changes in immune responses to antigens.

This study uses ABPP to identify cell wall synthesis inhibitors targeting Mycobacterium tuberculosis, showing that active compounds inhibit serine hydrolases involved in cell wall and lipid metabolism.

This study investigates salt-induced structural transitions in the DNA-interacting protein SSB using magnetic tweezers and infrared spectroscopy, revealing discontinuous thermodynamic behavior at binding mode transitions.

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

This study identifies and validates SARS-CoV-2 CD8+ T cell epitopes, demonstrates their cross-presentation, and shows the efficacy of peptide vaccines in transgenic mice.

The paper shows that mice with a diverse wild microbiota develop stronger allergic inflammation compared to those without microbial exposure.

This study shows mTORC2 promotes Tfh differentiation and disrupts Treg homeostasis, contributing to systemic autoimmunity, and suggests mTORC2 as a potential therapeutic target.

This study identifies NPR1 and EDS1 as interacting coactivators that synergistically activate PR genes and plant defenses through Mediator complex recruitment and mutual stabilization.

This study reports the crystal structures and biochemical characterization of SOQ1 lumenal domains, revealing their structural organization and potential regulatory mechanisms in suppressing qH.

This paper describes the development of a modified Atezolizumab (Maxatezo) with improved anti-tumor efficacy and reduced anti-drug antibody formation in vivo.

This study identifies BIRG1 as a chloride efflux transporter in rice that regulates grain size and salt tolerance by controlling chloride homeostasis.

This study combines X-ray computed tomography and root pulling force measurements to improve 3D root system architecture analysis in maize.

This study shows that HMGB1 is sequestered by plasma sialoglycoproteins at physiological pH but is released during sepsis when pH and zinc levels drop, leading to immune activation.

This study compares CWD detection methods in white-tailed deer, finding RT-QuIC more sensitive than ELISA and IHC, and that testing multiple tissues improves detection rates.

The paper reports high-resolution structures of PSI-LHCI-LHCII supercomplex in green algae, revealing the role of LhcbM5 in state transitions and supercomplex formation.

This study shows that natural selection on both amino acid sequences and expression levels determines ohnolog retention, providing a unified framework for understanding this evolutionary phenomenon.

This study investigates how cardiolipin and phosphatidylglycerol lipids induce structural and dynamic changes in cytochrome c, affecting its peroxidase activity during mitochondrial apoptosis.

The paper assembles a chromosome-scale, allele-aware autotetraploid genome of alfalfa cultivar Zhongmu-4 and identifies 101 SNPs associated with 27 agronomic traits using GWAS.

This paper re-examines fidelity-speed and fidelity-proofreading cost trade-offs in DNA replication under the exonuclease-proofreading mechanism using a first-passage method.

This study shows that Arabidopsis CIL and CIA2, paralogous genes involved in chloroplast development, have partially overlapping functions, with CIL localized to the nucleus and CIA2 possibly localized to chloroplasts.