Y. Shu

Meta-transcriptomic analysis of companion animal infectomes reveals their diversity and potential roles in animal and human disease

The paper analyzes meta-transcriptomic data from companion animals to identify microbial communities and assess zoonotic risks.

Integrative Omics Uncovers Low Tumorous Magnesium Content as A Driver Factor of Colorectal Cancer

This study identifies low tumorous magnesium content as a driver factor of colorectal cancer by showing its impact on gene mutations, EMT activation, and cell migration through DBN1 phosphorylation.

Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation

This study uses genome editing in adult mice with a MIR96 mutation to restore hearing, showing efficacy that improves with earlier intervention.

Extreme diversity of mycoviruses present in four strains of Rhizoctonia cerealis, the pathogen of wheat sharp eyespot

The paper analyzes viral genomes from four strains of Rhizoctonia cerealis, identifying 131 novel or unclassified mycoviruses and proposing new taxonomic classifications.

Conformational Changes Regulate Metal Coordination in the Catalytic Sites of Cas9

This study presents cryo-EM structures of AceCas9 at different states to show how conformational changes regulate metal coordination and catalytic activity.

PPRD: a comprehensive online database for expression analysis of ~45,000 plant public RNA-Seq libraries

PPRD integrates and curates ~45,000 plant RNA-seq libraries into a searchable database to facilitate expression analysis.

Asymmetric Pendrin Homodimer Reveals its Molecular Mechanism as Anion Exchanger

The paper determines the asymmetric homodimer structure of mouse pendrin using cryo-EM, revealing its electroneutral anion exchange mechanism and pathogenetic mutation properties.

Combined use of Candida Utilis and Idesia polycarpa var. Vestita Fruit Improve the Production Performance of Laying Quail

This study evaluates the effect of Idesia polycarpa fruit residues fermented feed additive on laying quail egg production and related performance metrics, finding improved egg production, reduced cholesterol, and enhanced lipid metabolism.

Exosomal miR-769-5p confers cisplatin resistance and tumorigenesis in gastric cancer

This study identifies exosomal miR-769-5p as a mediator of cisplatin resistance in gastric cancer by targeting CASP9 and promoting apoptosis evasion.

The possible fidelity-speed-proofreading cost trade-offs in DNA replication due to the exonuclease proofreading

This paper re-examines fidelity-speed and fidelity-proofreading cost trade-offs in DNA replication under the exonuclease-proofreading mechanism using a first-passage method.

Kinetic assays of DNA polymerase fidelity: a new theoretical perspective beyond Michaelis-Menten kinetics

This paper examines the theoretical basis of two DNA polymerase fidelity assays and shows they only accurately quantify proofreading efficiency under specific kinetic parameter constraints.

Genome-wide data inferring the evolution and population demography of the novel pneumonia coronavirus (SARS-CoV-2)

This study analyzes SARS-CoV-2 genome data to infer its evolution and population demography using phylogenetic and population genetics methods.

Mitochondrial dynamics and mitophagy are necessary for proper invasive growth in Rice Blast

This study shows that mitochondrial dynamics and mitophagy are essential for the invasive growth of Magnaporthe oryzae during rice blast disease.

Identification of genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses

This study identifies genome-wide nucleotide sites associated with mammalian virulence in influenza A viruses and develops machine-learning models to predict virulence.