M. Li

TopoRoot computes fine-grained root traits from maize root CT images, improving accuracy over existing methods and enabling automated analysis of root system architecture.

This study shows boron alleviates aluminum toxicity in Arabidopsis roots by restoring PIN2 endocytosis and auxin transport, reversing auxin depletion in the elongation zone.

This study identifies a resident state in influenza polymerase that enables smooth transitions between transcription and replication cycles through structural analysis.

This study investigates the inactivation effect of UVCLED on Acinetobacter baumannii, showing that high irradiance improves sterilization efficiency and causes distinct structural and genomic damage.

This study uses omics approaches to show Hematodinium parasites modulate crustacean immune responses through miRNA and proteomic changes.

The paper fits a mosquito density model to Guangzhou data, identifies non-identifiable parameters, simplifies the model, and validates its applicability across seasons.

This study identifies RPRM as a negative regulator of ATM levels through phosphorylation by CDK4/6, enhancing cellular sensitivity to genotoxic agents and radiation.

This study investigates the role of viruses in wastewater treatment plants, finding they can enhance contaminant degradation but also spread antibiotic resistance.

The paper identifies two transporters that regulate mitochondrial Zn2+ levels in C. elegans, showing their roles in maintaining mitochondrial homeostasis.

This study shows that Celastrol reduces colitis by modulating gut microbiota, improving immune balance, and increasing metabolites like pyruvate and adenosine.

This study develops a protocol for generating hyaline cartilage from hiPSC-derived multi-tissue organoids and identifies molecular pathways involved in its self-organized emergence and articular cartilage development.

The paper identifies genomic regions linked to yield and morphological traits in a maize mapping population, revealing local adaptation in highland environments.

This study identifies a non-bactericidal cathelicidin, PopuCATH, that prevents bacterial infection by enhancing phagocyte influx and reducing inflammation without direct antimicrobial activity.

This study examines gut microbiota composition in GDM patients before and after diet intervention, finding that diet affects the Firmicutes/Bacteroidetes ratio and specific taxa rather than altering the overall microbial pattern.

This study shows that virus-specific memory T cells reside in glioblastoma and can be reactivated to improve survival in a mouse model.

The paper develops a computational model to simulate tumor cell plasticity and immune escape after CAR-T therapy, finding that CAR-T stress induces tumor cells to transition into hematopoietic stem-like and myeloid-like cells, leading to relapse.

The paper introduces DeepHoF, a deep learning method to predict viral hosts, and applies it to SARS-CoV-2 to identify potential hosts and analyze host range uniformity during the pandemic.

The paper presents the cryo-EM structure of the human TACAN channel in a closed state and identifies key residues and cholesterol interactions involved in its function.

This study uses a real-time femtosecond laser and microfluidic device to guide axon outgrowth by creating netrin-1 gradients, achieving 92% guided axon growth.

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

TaBln1 negatively regulates wheat resistance to stripe rust by reducing Ca2+ influx through its interaction with TaCaM3 on the plasma membrane.

This study shows that complete depletion of linker histone H1 in Arabidopsis disrupts correlations between chromatin compartmentalization, DNA methylation, and gene expression.

This paper shows that oxidative phosphorylation (OXPHOS) generates most ATP in mouse ESCs and is essential for pluripotency by coupling with the hexosamine biosynthesis pathway to produce UDP-GlcNAc.

The paper identifies ICER as a host factor that contributes to HIV resistance in elite controllers by regulating HIV-1 replication through alternative splicing and promoter activity.

This study identifies how Mycoplasma ovipneumoniae evades alveolar macrophage clearance by altering apoptosis, phagosome maturation, and autophagy in sheep.

The paper screens 18,000 drugs for antiviral activity against SARS-CoV-2, identifies synergistic combinations of pyrimidine biosynthesis inhibitors and nucleoside analogs, and validates their efficacy in vitro and in vivo.

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

This study shows that introducing probiotic bacterial consortia to tomato plants enhances growth by increasing rhizosphere microbiome diversity and abundance of rare taxa, rather than directly adding beneficial traits.