M. Liu

This paper engineers a precise adenine base editor, ABE9, with reduced bystander mutations and off-target effects, enabling efficient and accurate A-to-G editing in mouse and rat embryos.

This study characterizes the antigenic properties of the SARS-CoV-2 Omicron subvariant BA.2.75, showing increased neutralization resistance to vaccinated sera and specific monoclonal antibodies.

This study evaluates the neutralization of SARS-CoV-2 Omicron sublineages by different vaccination regimens and finds that 4-dose mRNA vaccines provide lower neutralization compared to 2-dose plus BA.1 infection.

The paper characterizes the Piks allele of the rice immune receptor Pik, showing it does not recognize known AvrPik effectors of the rice blast fungus, suggesting a novel recognition mechanism.

The paper identifies SNULs, noncoding RNAs that form nucleolar territories on NOR chromosomes and regulate rRNA expression by influencing pre-rRNA sorting and processing.

The paper identifies RPG as required for infection thread formation in Lotus japonicus and shows it interacts with CERBERUS to mediate polarity growth driven by nuclear migration.

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

This study identifies Rab38 as a physiological regulator of LRRK2 function in melanocytes, showing it enhances LRRK2 membrane recruitment and substrate phosphorylation.

This study evaluates the neutralization of Omicron sublineages and Deltacron by BNT162b2 vaccine or BA.1 infection, finding BA.4/5 shows highest evasion.

This study examines the composition and functional properties of hemp seed protein isolates from different cultivars, finding that protein class ratios significantly affect solubility, foam capacity, and emulsifying properties.

This study analyzes the nasal microbiome of healthy young adults, revealing sex-specific differences in composition and ecological stability between males and females.

This study identifies introgressed haplotypes from wild sheep species associated with morphological traits in domestic sheep using whole-genome sequencing.

This paper presents an integrated platform for high-throughput single-molecule localization microscopy (SMLM) that enables imaging of 10,000 cells per day.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

This study assesses neutralizing antibody titers in vaccinated individuals who experienced SARS-CoV-2 Delta breakthrough infections, finding that all had titers below 70.

The paper assesses cross-neutralization of Omicron BA.1 sera against BA.2, BA.3, and a pre-Omicron strain, finding reduced neutralizing titers against heterologous variants.

This study identifies m6A modification patterns and functions during sexual reproduction in Chlamydomonas reinhardtii, showing its role in regulating microtubule-based processes.

This paper shows a chemical molecule enhances the differentiation of biliary duct organoids into insulin-secreting cells, improving glucose sensitivity in diabetic mice.

This study identifies SOX4 as a critical regulator of human endometrial decidualization by modulating PGR stability and FOXO1 expression, linking its dysregulation to infertility and pregnancy complications.

This study infects neonate and adult mice with dengue virus via the nasal route, showing viral tropism and replication in multiple tissues, suggesting respiratory transmission as a potential non-vector route.

The paper presents near-atomic cryo-EM structures of the Xenopus laevis nuclear pore complex cytoplasmic ring, revealing its scaffold composition and organization.

This study characterizes the HERV-K (HML-8) group in the human genome, identifying 40 proviruses and 5 solo LTR elements and determining their integration time and genomic distribution.

This study evaluates the effect of compound Tinglizi Decoction on the non-classical pyroptosis pathway in rats with COPD-related pulmonary hypertension, showing reduced caspase-11, GSDMD, and IL-6 levels.

This study designs bispecific antibodies from non-Omicron neutralizing antibodies that effectively neutralize the Omicron variant and related sarbecoviruses.

This study shows JQ-1 reduces liver granuloma size and egg production in Schistosoma japonicum-infected mice by inhibiting reproductive system development and gene expression.

This study identifies CD39 as a marker for tumor-reactive CD8 T cells in lung cancer, showing its association with clinical outcomes and response to immune checkpoint therapy.

This study shows that hemagglutinin stability affects influenza A virus susceptibility to Arbidol, with stabilized mutants being more sensitive and destabilized ones more resistant.

This study identifies how SteD, a Salmonella effector, targets and traffics to MHCII compartments by hijacking AP1-mediated vesicular trafficking.

Antibodies from 3-dose vaccinated individuals neutralize Omicron and other variants, with some being ultrapotent and broadly reactive.