M. Liu

This paper describes the construction of an E. coli strain with suppressed overflow metabolism, leading to improved chemical and protein production.

This study establishes and evaluates rat models of cervical spondylopathy with Yin deficiency syndrome through sleep deprivation and behavioral assessments.

This paper integrates deep neural networks with finite element methods to improve biomechanical analysis of the human aorta, reducing errors and computational time.

PyTorch-FEA improves computational efficiency and accuracy in biomechanical analysis of human aorta using autograd and deep learning.

The paper analyzes the receptor affinity and antibody evasion properties of SARS-CoV-2 BA.2.75 subvariants, identifying two evolutionary pathways and three mutations that influence their virological features.

This paper introduces a hierarchical strategy using CXMS and AlphaFold2 to analyze protein dynamics in vivo, focusing on IDPs and multi-domain proteins.

This study shows ATF6 enhances TH2 and TH17 cell responses and contributes to mixed granulocytic airway inflammation, suggesting ATF6 inhibition as a potential therapy for steroid-resistant asthma.

The paper determines cryo-EM structures of microtubules composed of different α-tubulin isotypes and finds that α4A/β2A microtubules show longitudinal contraction compared to other isotype combinations.

This study uses E. coli outer membrane vesicles to deliver target proteins into eukaryotic cells with high efficiency and enables direct labeling of proteins within vesicles.

The paper shows that anti-CTLA-4 ADC treatment causes B cell depletion via T cell hyper-proliferation and regulatory T cell impairment in CTLA-4 knock-in mice.

This study creates a spatial transcriptomic atlas of tomato callus during shoot regeneration, identifying cell types and developmental trajectories.

The paper uses AlphaFold2 to identify and validate interactions of Mint proteins with Munc18-1 and their broader interactome, revealing structural and functional insights into neuronal membrane trafficking.

This paper introduces a method for rapid nanobody screening that preserves library diversity without subcloning or amplification bias, producing functional nanobodies against DR5 and Pfu DNA polymerase.

This study compares the effects of DMPA and NuvaRing on genital epithelial barrier function in rhesus macaques, finding greater compromise with DMPA.

This study shows that Wg signaling reduces lipid accumulation in Drosophila adipocytes by repressing lipogenesis and fatty acid β-oxidation while promoting lipolysis.

The paper analyzes microbial diversity in ancestral halls in Guangdong Province, identifying cellulose- and lignin-degrading microbes and evaluating biocides for wood preservation.

This study shows TRB proteins recruit JMJ14 to demethylate H3K4me3 and coordinate with PRC2 to repress target genes.

The paper introduces a nanofluidic device that enables real-time combinatorial exchange of buffers and dynamic DNA manipulation to study protein-DNA interactions.

This study determines the cryo-EM structure of AMBRA1 bound to DDB1, revealing how AMBRA1 recruits substrates for ubiquitination and its role in autophagy and cell-cycle regulation.

This study shows that Fc-gamma receptor-dependent antibody effector functions are necessary for vaccine protection against antigenic variants of SARS-CoV-2, including Omicron.

The paper isolates the first host-associated Psychrilyobacter strain from abalone gut and identifies its functional roles in host metabolism and health.

This study shows that new SARS-CoV-2 BQ and XBB subvariants have significantly reduced neutralization by vaccines and monoclonal antibodies, suggesting a threat to current immunity.

This paper discovers a macrocyclic peptide that inhibits SARS-CoV-2 and related sarbecoviruses by targeting a conserved site in the spike protein, offering a potential broad-spectrum antiviral.

This study evaluates the neutralization effectiveness of parental mRNA vaccines and BA.5-bivalent boosters against new SARS-CoV-2 variants, showing limited neutralization against BA.2.75.2, BQ.1.1, and XBB.1.

This study shows that ploidy affects metabolism by altering cell size and plasma membrane energetics in Xenopus embryos.

This study develops a high-affinity, specific TCR targeting NY-ESO-1 through engineering and screening, showing efficacy in tumor models and approval for clinical trials.

This study links SARS-CoV-2 spike-induced syncytia to cellular senescence and exacerbated heart failure, showing that senolytic drugs and WNK1 inhibitors can mitigate cardiac damage.

This study identifies manipulative cheating as a new form of social cheating that involves evolving strategies to both exploit and resist exploitation, leading to dynamic oscillations in social interactions.

This study investigates how nonlinear hyperelastic properties of arterial tissue affect pulse wave velocity using a unified-fiber-distribution model, showing increased PWV with higher circumferential fiber content and non-monotonic dependencies on fiber and matrix stiffness.

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.