T. Jin

Habitat fragmentation mediates the mechanisms underlying long-term climate-driven thermophilization in birds

The paper examines how habitat fragmentation influences climate-driven changes in bird communities over time, finding that fragmentation affects colonization and extinction rates of warm- and cold-adapted species.

Hypoxia-induced circSTT3A maintains Breast Cancer Stem Cell formation by Stabilizing PGK1 protein

This study identifies circSTT3A as a hypoxia-induced circular RNA that stabilizes PGK1 protein to promote breast cancer stem cell formation and chemotherapy resistance.

Genetic and histological correlation between the musk gland and skin of Chinese forest musk deer

The paper investigates the correlation between skin and musk glands in Chinese forest musk deer, finding strong gene expression overlap and roles for Sox9, Caveolin1, and AR in both tissues.

CARD8 negatively regulates NLRP1 inflammasome activation level by interaction with NLRP1

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

Selection and validation of reference genes for quantitative real-time polymerase chain reaction in Serratia ureilytica DW2

This study identifies and validates stable reference genes for RT-qPCR in Serratia ureilytica DW2 under various conditions.

A cocktail containing two synergetic antibodies broadly neutralizes SARS-CoV-2 and its variants including Omicron BA.1 and BA.2

This paper identifies a potent antibody cocktail that synergistically neutralizes SARS-CoV-2 and its variants, including Omicron BA.1 and BA.2.

Hetero-bivalent Nanobodies Provide Broad-spectrum Protection against SARS-CoV-2 Variants of Concern including Omicron

This paper develops hetero-bivalent nanobodies that neutralize multiple SARS-CoV-2 variants, including Omicron, and show protective effects in vivo.

S100A4 exerts robust mucosal adjuvant activity for co-administered antigens in mice

This study identifies S100A4 as a potent mucosal adjuvant in mice that enhances antigen-specific immune responses without adverse effects.

Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

Potent in vitro Neutralization of SARS-CoV-2 by Hetero-bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain

This paper develops and characterizes SARS-CoV-2 RBD-specific alpaca nanobodies, showing improved binding affinity and neutralizing potency through bivalent engineering.

Dual regulation of the actin cytoskeleton by CARMIL-GAP

This paper identifies CARMIL-GAP as a Dictyostelium protein that regulates actin dynamics by GAP activity on Rac1 and capping protein, showing its critical role in phagocytosis and chemotaxis.

Sequencing of clinical samples reveals that adaptation keeps establishing during H7N9 virus infection in humans

This study analyzes H7N9 virus genome mutations in human clinical samples to identify potential adaptations during infection.

GPCR-mediated Activation of PLCg2 Initiates Dysregulated Recruitment of Neutrophils in Cold-induced Urticaria in PLAID Patients

This study shows that GPCR-mediated PLCγ2 activation drives neutrophil dysregulation in cold-induced urticaria in PLAID patients.

Ras Inhibitor CAPRI Enables Neutrophils to Chemotax Through a Higher-Concentration Range of Gradients

This study shows that CAPRI enables human neutrophils to chemotax through a broader range of chemoattractant gradients by controlling Ras adaptation and sensitivity.