Author

N. Yachie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:CRISPR screen· 2 Research Focus:perturbation response prediction· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1

Frequent Co-Authors

H. Aburatani· 2 shared N. Masuyama· 2 shared S. Ishiguro· 2 shared A. Adel· 1 shared A. Baccouche· 1 shared A. Cisneros· 1 shared A. J. Genot· 1 shared A. K. Dube· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

H. Aburatani

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Highly efficient transgenic mouse production using piggyBac and its application to rapid phenotyping at the founder generation

E. Okamura, S. Mizuno, S. Matsumoto, K. Murata, Y. Tanimoto, D. T. H. Tra, H. Suzuki, W. Kang, T. Ema, K. Morimoto, K. Kato, T. Matsumoto, N. Masuyama, Y. Kijima, T. Morimura, , M. Ema

This study improves transgenic mouse production efficiency using piggyBac, enabling phenotyping in the founder generation and demonstrating application with bacterial artificial chromosome transgenes.

bioRxiv · Dec 10, 2023 · PreprintBioengineering

Pooled CRISPR screening of high-content cellular phenotypes by ghost cytometry

A. Tsubouchi, Y. An, Y. Kawamura, Y. Yanagihashi, Y. Murata, K. Teranishi, S. Ishiguro, H. Aburatani, N. Yachie, S. Ota

The paper introduces a ghost cytometry-based method for fast pooled CRISPR screening of high-content cellular phenotypes, including fluorescence and label-free modes, enabling genome-wide analysis of gene effects on cellular processes.

bioRxiv · Jan 26, 2023 · PreprintCell Biology

License to cut: Smart RNA guides for conditional control of CRISPR-Cas9

A. Baccouche, A. Adel, N. Yachie, T. Fujii, A. J. Genot

This paper introduces smart RNA guides that conditionally activate CRISPR-Cas9 in response to specific RNA openers, demonstrating flexibility with miRNA and Boolean logic circuits in mammalian cells.

bioRxiv · Oct 26, 2022 · PreprintBioengineering

A single CRISPR base editor to induce simultaneous C-to-T and A-to-G mutations

R. C. Sakata, S. Ishiguro, H. Mori, M. Tanaka, M. Seki, N. Masuyama, K. Nishida, H. Nishimasu, A. Kondo, O. Nureki, M. Tomita, H. Aburatani, N. Yachie

This paper introduces Target-ACE, a CRISPR base editor that induces both C-to-T and A-to-G mutations, showing higher efficiency than using separate editors.

bioRxiv · Aug 8, 2019 · PreprintBioengineering

The role of structural pleiotropy and regulatory evolution in the retention of heteromers of paralogs

A. Marchant, A. Cisneros, A. K. Dube, I. Gagnon-Arsenault, D. Ascencio, H. Jain, S. Aube, C. Eberlein, D. Evans-Yamamoto, N. Yachie, C. R. Landry

The paper investigates how structural pleiotropy and regulatory evolution influence the retention of heteromers formed by paralogs in budding yeast.

bioRxiv · Jul 16, 2019Evolutionary Biology