R. Li

This study identifies Gas1's role in regulating cytosolic proteostasis through the MAGIC pathway and UPS in yeast.

This study shows that syntenin and CD63 promote exosome biogenesis by blocking CD63 endocytosis, allowing it to accumulate at the plasma membrane where exosomes originate.

This study identifies artefacts in 2D widefield microscopy of microbial cells caused by diffraction and projection effects, and proposes experimental designs and machine learning methods to improve quantification accuracy.

This study shows exercise reduces flow recirculation and activates SCD1 to produce anti-inflammatory metabolites in endothelial cells.

This study shows that aging impairs vascular smooth muscle cell mechanosensation via Piezo1 hyperactivity, and inhibiting Piezo1 can alleviate vascular aging.

The paper generates a high-confidence binary protein interaction network for Drosophila using yeast two-hybrid screens and integrates it with existing data to create a comprehensive reference network.

The paper shows doxorubicin inhibits MoPSD2, a phosphatidylserine decarboxylase in Magnaporthe oryzae, reducing fungal growth and crop disease severity.

The paper identifies a novel CD9+Il1rn+ reparative macrophage subset in infarcted hearts modulated by CCN2 from Nlrx1-deficient cardiomyocytes, showing potential therapeutic implications for myocardial healing.

Rice OsHAK18 mediates shoot-to-root potassium and sodium circulation and source-to-sink sugar transport, improving potassium use efficiency and grain yield.

This study identifies two unique myeloid-derived suppressor cell populations in glioblastoma that promote tumor growth and immune evasion.

The paper shows that expanded intronic TNR repeats in IIL1 cause growth defects in Arabidopsis by increasing intron-retained transcripts and disrupting protein interactions essential for leaf development.

This study shows that SOX17 deficiency in endothelial cells causes pulmonary hypertension via E2F1 signaling, suggesting E2F1 as a therapeutic target in PAH.

This study shows dopamine promotes Klebsiella quasivariicola growth and inflammation in macrophage co-culture, exacerbating lung injury in mice.

The paper identifies a clathrin-mediated trafficking pathway essential for sFLT1/VEGFR1 secretion from endothelial cells, revealing key components and their roles in vessel sprouting.

This study investigates the relationship between breast cancer and gut microbiome by analyzing fecal samples from mice with induced breast tumors, finding changes in microbial composition and signaling pathways.

The paper introduces TaCT, a method to fluorescently label cells based on molecular force through adhesion receptors, and demonstrates its use in fibroblasts and mouse platelets.

The paper catalogs and profiles the gut virome in Chinese populations, identifying novel viruses and disease-associated viral signatures.

This study investigates H2S-induced suppression of neuronal activity and calcium dysregulation, identifying TRP channels as key targets for therapeutic intervention.

This study shows that wheat genotype affects root microbiome more than rhizosphere or soil, and this effect varies with time and plant compartment.

The paper discovers a new aphid-transmitted rice virus, RTIV, from wild rice plants and shows it causes low-tillering disease in rice cultivars.

MCATS detects cell-generated forces using CRISPR-Cas12a, showing drug effects on platelet forces and identifying platelet dysfunction after cardiopulmonary bypass.

This study investigates how metabolic acids like citrate and lactate influence the 3D architecture of bone mineral through synthetic apatite formation.

This study evaluates the replicative ability and pathogenicity of SARS-CoV-2 BA.2.75 isolates in Syrian hamsters, finding higher lung replication and focal pneumonia compared to BA.2 and BA.5.

This study identifies Breg as a batokine that regulates adipose thermogenesis and glucose homeostasis, showing its role in energy metabolism and potential therapeutic applications.

The paper investigates NRF2's role in pulmonary artery endothelial and smooth muscle cells under hypoxia, finding differential regulation and effects on proliferation and migration.

The paper introduces Phosphosite Scanning to identify functionally important phosphosites in multisite phosphorylated domains, demonstrating its application to Hcm1 in yeast.

The paper identifies two point mutations in PCDH1 that disrupt ANDV recognition and protect against lethal infection in Syrian hamsters.

This study uses single-cell sequencing to analyze immune cell dynamics across human lifespan, identifying age-related changes in T cell function, cell interactions, and B cell subsets.

This study identifies MsGOBP2 and MsOR3 as molecular factors mediating Z11-16: Ald-induced host-feeding preference in Mythimna separata larvae.

This study investigates giant panda reproductive physiology, finding that pregnancy lasts 42 days and involves a triphasic progesterone profile with CL reactivation postponed to shorten the active luteal phase.