Paul W. Harms

An immunocompetent Merkel cell carcinoma model for preclinical studies

This paper develops an immunocompetent mouse model of Merkel cell carcinoma that forms tumors and metastases, showing that LSD1 inhibitors effectively reduce tumor growth and metastasis.

Multiomic Analysis Reveals an IFN-driven Cellular Landscape Effectively Targeted by Ruxolitinib in Hailey-Hailey Disease

This study uses multiomic analysis to identify IFN signaling as a key driver in Hailey-Hailey disease and shows that ruxolitinib treatment reduces inflammation and improves patient outcomes.

Positionally distinct interferon stimulated dermal immune acting fibroblasts promote neutrophil recruitment in Sweet's syndrome

This study identifies interferon-responsive dermal fibroblasts in Sweet's syndrome that promote neutrophil recruitment through chemokine expression and spatial positioning.

A Transcriptomic Atlas of Healthy Human Skin Links Regional Identity to Inflammatory Disease.

This study creates a high-resolution single-cell atlas of healthy human skin, revealing region-specific transcriptional networks and their links to inflammatory diseases.

ERK hyperactivation in epidermal keratinocytes impairs intercellular adhesion and drives Grover disease pathology

This study shows ERK hyperactivation in keratinocytes causes impaired adhesion and drives Grover disease, supporting MEK inhibition as a potential therapy.

Transcriptional profiling of rare acantholytic disorders suggests common mechanisms of pathogenesis

This paper performs RNA-seq on skin samples from three acantholytic diseases to identify shared transcriptomic features and mechanisms of pathogenesis.