S. Huang

The paper finds that conservative amino acid changes are more common in fixed and standing missense variations of slow evolving proteins, suggesting these variations are more neutral and suitable for phylogenetic inferences.

The paper develops a droplet microfluidics platform to isolate and culture human gut bacteria, demonstrating its use in studying metabolic variation and growth kinetics.

This paper investigates cancer cell growth at low densities and finds that an Allee effect model better describes growth kinetics than exponential growth, suggesting cooperative behavior among cells.

The paper examines age and sex effects on gut microbial diversity across four adult cohorts, finding age-related diversity increases in young adults and sex differences in some groups.

The paper curates 30 transcriptomic datasets from GEO to study IgE-mediated atopic diseases and provides an online tool for data visualization and metadata annotation.

The paper analyzes ancient and present-day HBV genomes to reconstruct the evolutionary history of hepatitis B virus, identifying genotype G in ancient isolates and placing genotype D as the most basal branch.

This study analyzes de novo mutations in autism spectrum disorders and finds they are less frequent in ASD compared to controls, suggesting increased deleterious effects in ASD.

The paper develops a model for studying small cell lung cancers by generating pulmonary neuro-endocrine cells and tumors from human embryonic stem cells through genetic manipulation.

This paper identifies AP2IV-4 as a transcriptional repressor that suppresses bradyzoite gene expression in tachyzoites, essential for establishing chronic Toxoplasma infection.

This study shows that sublancin enhances macrophage function and protects mice from MRSA infection by activating innate immunity and improving T cell responses.

This study identifies Jag1/Notch2 as a key driver of kidney fibrosis through Tfam-mediated metabolic reprogramming in mouse models.

The paper analyzes splicing evolution across human, chimpanzee, and macaque lineages, finding that changes in exon inclusion frequency are more functionally relevant than constitutive-to-alternative transitions.

The paper uses single-cell RNA sequencing to identify novel kidney cell types and Notch-mediated plasticity in collecting duct cells, which is defective in chronic kidney disease.

The paper analyzes the evolutionary ages of cancer-related genes and finds they are enriched for pre-Metazoan genes, suggesting cancer reverts to an ancestral state.

The paper analyzes the evolution and adaptation of H7N9 influenza viruses in China, identifying lineage-specific mutations and high-pathogenicity strains.

The paper investigates the role of minor alleles in schizophrenia using public datasets, finding higher minor allele content in cases and identifying SNPs that predict schizophrenia with 100% certainty.

The paper examines genetic equidistance at the DNA level across 15 proteomes, confirming the maximum genetic diversity hypothesis and showing species complexity, not time, determines equidistance.

This study identifies AP2IX-4 as a regulator of gene expression during bradyzoite development in Toxoplasma gondii, showing its role in cyst formation and virulence.