S. Huang

This study shows that E. coli lacking RpoS has reduced colonization ability in human intestinal organoids but not in germ-free mice, indicating different stress environments in these models.

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

The paper analyzes synonymous sites in SARS-CoV-2 genes to assess translational efficiency trends and their implications for viral adaptation and epidemic growth.

The paper reports cryo-EM structures of GPBAR-Gs complexes, revealing structural features of bile acid recognition, allosteric effects, and biased signaling.

This study evaluates the virucidal activity and safety of Povidone-iodine in-situ gel formulations against SARS-CoV-2 in vitro and in vivo.

This study identifies PSGL-1 as an HIV restriction factor that inhibits HIV DNA synthesis and virion infectivity by restricting actin dynamics and sequestering HIV envelope proteins.

This study uses single-cell RNA-sequencing to identify a transitional cell state in peripheral neuroblastic tumors associated with poor prognosis and therapeutic targets.

This study quantifies the heterogeneous timing of asexual cycles in Plasmodium falciparum using time-lapse microscopy and finds that unsynchronized cultures have a bimodal burst time distribution and that artificial synchronization does not fundamentally alter cycle dynamics.

The paper develops non-toxic virucidal macromolecules effective against multiple influenza strains in vitro and in vivo.

This paper analyzes ancient Y chromosome data to support the Asia origin model for modern human paternal lineages over the African origin model.

This study identifies a non-canonical histone acetyltransferase in CYC/TB1-like proteins that regulates plant architecture by modifying histone H3 and activating gene expression.

This study compares the effects of different fertilization patterns on soil microbial diversity, structure, and function in greenhouse vegetable production systems, finding that higher manure substitution improves soil quality and microbial activity.

The paper investigates the genetic basis of rumen evolution by comparing transcriptomes and genomic data across ruminants, camels, and cetaceans, identifying key genetic innovations.

The paper profiles miRNAs and uses degradome sequencing to study their role in CMS regulation during anther development in pepper, identifying differentially expressed miRNAs and their target transcripts.

This study tracks the decline of mcr-1 prevalence and genetic changes in mcr-1-positive Escherichia coli after China banned colistin use in animal feed.

The paper shows that CLPP2 in Arabidopsis thaliana aids in coordinating and assembling protein complexes encoded by both mitochondrial and nuclear genomes, affecting mitochondrial protein homeostasis.

The paper shows that core-2 O-glycans are necessary for galectin-3 to bind lubricin, and this interaction is reduced in late-stage osteoarthritis.

The paper identifies sensory neurons innervating lymph nodes and shows they modulate gene expression in endothelium, stromal cells, and innate leukocytes through direct communication.

The paper compares the Out of East Asia and African Eve models of modern human origins using ancient mtDNA data, finding that basal R is older than basal N, supporting the East Asia model.

The paper tests the molecular clock and neutral theory using ancient proteomes and finds that genetic distances in ancient proteins are not closer to an outgroup than modern orthologs, supporting the MGD theory over the molecular clock.

This study shows that cathepsin G degrades lubricin in synovial fluid, contributing to osteoarthritis pathogenesis by reducing joint lubrication.

PulseDIA improves DIA-MS specificity and sensitivity by using gas phase fractionation, achieving higher protein identification rates in cancer proteomics.

This study shows Ffar4 resolves inflammation in the heart by sensing fatty acids and promoting anti-inflammatory oxylipin production, preventing cardiac remodeling.

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

This study shows RanGTP regulates ciliary trafficking of KAP3 independently of its nuclear roles, using Chlamydomonas and mammalian cells.

This paper introduces NIPSS, a nanopore sequencing method for direct miRNA sequencing, demonstrating single-molecule resolution and potential applications in cancer diagnostics and therapeutics.

This study identifies GH1, a SAC phosphatase in rice, which hydrolyzes PI4P and PI(4,5)P2, affecting actin cytoskeleton and cell elongation during plant development.

This study identifies FOR1 and PRF1 in Chlamydomonas reinhardtii as key regulators of rapid F-actin assembly for fertilization tubule formation.

This study analyzes the mitochondrial genome diversity of 192 S. pombe isolates, identifying 69 sequence types, two new introns, and two divergent clades, suggesting a split of ancestral lineages around 31 million generations ago.

The paper challenges the Recent Out of Africa model by proposing multiregional evolution of autosomes and East Asian origin of modern Y and mtDNA through hybridization with archaic humans.