S. Sinha

The paper identifies benztropine and DX600 as inhibitors of SARS-CoV-2 infection using a screening platform with human embryonic stem cell-derived cardiomyocytes.

The paper develops ATAC-Array, a low-cost chromatin accessibility assay, and shows it predicts pancreatic cancer prognosis based on chromatin accessibility patterns.

The paper investigates whether SARS-CoV-2 uses circulating immune cells to spread in severe COVID-19 patients and finds that these cells are not actively infected and not a source of viral dissemination.

This study shows that HIV-1 broadly neutralizing antibodies and plasma from HIV-1 infected children can cross-neutralize SARS-CoV-2 by targeting conserved epitopes and glycans on the spike protein.

The paper uses t-SNE to reveal phase separation in tumors based on cell movement patterns driven by self-generated forces.

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

This study identifies distinct roles for YAP and TAZ in NSCLC, showing YAP regulates cell cycle and TAZ regulates extracellular matrix, with differential impacts on growth and migration.

This study shows that tracer particles in growing cancer spheroids exhibit sub- and super-diffusive behavior due to cell proliferation and apoptosis, without affecting cell dynamics.

This paper predicts patient response to cancer therapies using computationally derived genetic interactions across multiple tumor transcriptomics datasets.

The paper shows that cell-cell adhesion strength influences tumor growth rates through a pressure-adhesion feedback loop, with an optimal adhesion level maximizing proliferation.

The paper compares theoretical simulations and experimental data on cell movement in tumor spheroids, revealing distinct subdiffusive and superdiffusive dynamics in core and peripheral cells.

The paper identifies p53, KRAS, and VHL mutations as being selected during CRISPR-Cas9 editing through computational and experimental analysis.

This paper presents a low-cost hearing aid (LoCHAid) for age-related hearing loss, showing it meets key performance standards and is affordable for widespread use.

This study examines how different R273 mutations in p53 affect structural stability, aggregation, and toxicity, revealing distinct molecular mechanisms that may contribute to varied cancer outcomes.

The paper compares genomic features between African American and European American lung cancers, finding higher genomic instability and homologous recombination-deficiency in African American tumors.

KnowEnG is a cloud-based platform that provides tools for analyzing genomics data using knowledge-guided data-mining and machine learning, demonstrating its utility in cancer research.

This paper introduces a 3D-printed hand-powered centrifuge for use in remote and educational settings, demonstrating its ability to perform centrifugation for biomarker applications and nucleotide extractions.

This study examines how chromatin accessibility and sequence changes influence the evolutionary divergence of transcription factor binding in Drosophila species.

The paper identifies a competence-regulated toxin-antitoxin system in Haemophilus influenzae, showing that the toxin gene is inactivated in many strains and may downregulate protein synthesis under starvation.

The paper studies collective cell migration in tumor evolution, finding that growth rate influences the transition from glassy to super-diffusive behavior and reveals super-diffusion's universality in non-equilibrium systems.

This study shows that the MAPK signaling cascade exhibits persistent adaptive responses and memory-like behavior due to diverse relaxation time-scales, even without explicit feedback.

This study introduces PACER, a network embedding method to identify pathways associated with chemosensitivity by integrating gene expression and molecular network data.