S. Xu

The paper introduces a multi-camera array microscope (MCAM) that enables high-resolution, multi-scale imaging of behavior and neural activity in model organisms.

This study identifies the transcriptomic differences between sexual and asexual reproduction in Daphnia pulex and D. pulicaria, showing under-regulation of meiosis and cell-cycle genes and up-regulation of metabolic genes in asexual reproduction.

This study shows that mitochondrial UPR suppresses wounding-induced innate immunity in C. elegans epidermis by inhibiting ATFS-1 and modulating downstream signaling pathways.

This study identifies specific HA mutations in H9N2 avian influenza virus that influence antigenic variation and immune escape from vaccine antibodies.

This paper demonstrates that intranasal nanobody Nb22 provides short-term instantaneous prophylaxis and effective treatment against SARS-CoV-2 in hACE2 mice, with ultrahigh potency and long-lasting retention in the respiratory system.

The paper examines the transcriptomic differences in obligate parthenogenetic Daphnia isolates compared to cyclically parthenogenetic parental species, identifying underdominant and overdominant gene expression patterns linked to meiosis and metabolic pathways.

This study shows that the cGAS variant rs610913 maintains a baseline antiviral state, slightly altering susceptibility to viral infections without gross phenotypic differences.

This paper introduces a chemogenetic switch for CAR-T cells using HCV-NS3 protease, enabling controlled activation through ASV concentration modulation.

The paper analyzes chromosomal rearrangements in Daphnia species to show their role in preserving adaptive divergence during ecological speciation.

This study investigates how hyperproteinemia disrupts blood cell homeostasis in an invertebrate model, identifying novel signaling pathways and potential biomarkers.

This study identifies KPNB1 and RUVBL2 as key regulators of NFAT5's unconventional tonicity-dependent nuclear trafficking.

The paper evaluates MPro inhibitors for SARS-CoV-2, finding MPI8 selectively inhibits both MPro and host cathepsin L, enhancing antiviral efficacy with reduced toxicity.

This paper evaluates the cellular potency of SARS-CoV-2 MPro inhibitors using a fluorescent flow cytometry assay, revealing that most inhibitors have weak cellular activity despite strong antiviral effects.

This study screens inhibitors against SARS-CoV-2 PLpro, identifying several potent compounds with IC50 values below 60 μM, including SJB2-043 with an IC50 of 0.56 μM.

This study compares the efficacy of ancestral RBD, S1, and S-trimer vaccines against SARS-CoV-2 variants B.1.1.7, B.1.351, and B.1.617.1, finding that RBD and S-trimer induce higher neutralizing titers and maintain effectiveness against variants.

This study shows that Tmem138 is essential for rhodopsin transport across the photoreceptor connecting cilium and outer segment biogenesis, with its absence causing photoreceptor degeneration.

The paper designs and evaluates Vitamin E analogs with targeting and cleavable features to reduce Doxorubicin cardiotoxicity in cancer treatment.

This study investigates how specific amino acids in the DNA-binding domain of CcpA affect carbon source utilization in Bacillus licheniformis through in vitro and in vivo experiments.

The paper sequenced two mangrove species to show extensive gene flow after speciation, with many small introgression blocks and genomic islets contributing to speciation.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This study shows SKAP2 is essential for neutrophil ROS production in response to C-type lectin receptors and Candida infections, expanding its role beyond antibacterial immunity.

This study shows sulfur limitation increases duckweed starch yield without reducing growth, making it a promising method for biofuel production.

This study shows that activating KLF2 reduces endothelial dysfunction in COVID-19 by decreasing monocyte adhesion and inflammation.

This paper describes an AAV-mediated in vivo CAR gene therapy that generates CAR T cells within the host, leading to tumor regression in a humanized mouse model.

Nb15-NbH-Nb15, a bispecific nanobody with a heterotrimeric configuration, showed potent neutralization of SARS-CoV-2 in vitro and provided complete protection against infection in hACE2 mice via intranasal administration.

This study evaluates a recombinant chimpanzee adenovirus vaccine expressing a dimeric tandem-repeat RBD of SARS-CoV-2, showing enhanced immune responses and protection in mice.

This study investigates the antibacterial activity of a plant lipase, PLIP1, against gram-negative bacteria and explores its potential as a novel antimicrobial agent.

This paper introduces a polymer gel matched to water's refractive index, enabling high-resolution imaging of living cells and organisms in thick layers.

The paper investigates the origin and timing of Denisovan introgression into Tibetans at the EPAS1 locus, finding an East Asian-specific introgression event around 43,000 years ago followed by selection 12,000 years ago.