S. Xu

This study identifies compound 13 as a potent ENL inhibitor with favorable pharmacokinetic properties for treating AML with MLL-fusion mutations.

This study shows herbivory-induced responses in plants can evolve rapidly and increase resistance to herbivores through experimental evolution.

The paper develops an automated software tool for processing single-molecule force spectroscopy data, improving efficiency and reducing errors in fitting force-extension curves.

The paper shows that clonal neutrophil progenitors have predestined transcriptional and epigenetic heterogeneity that influences their response to Candida infections.

This study investigates the genetic mechanisms of obligate parthenogenesis in Daphnia pulex by comparing gene expression and alternative splicing in subitaneous and resting egg production.

This study shows that natural rubber reduces herbivory and alters the root microbiome in a herbivore-dependent manner in Russian dandelion.

This paper develops PADLE, a phage-assisted method to evolve potent HDAC8 inhibitors, identifying two highly selective and potent inhibitors with sub-nanomolar Ki values.

This study identifies a microglia-CD4+ T cell interaction that enhances anti-glioblastoma immunity through IFN-gamma-mediated tumor surveillance and phagocytosis.

This paper introduces a method to image endogenous mRNAs in live animals with high temporal resolution and applies it to study gene expression dynamics in C. elegans epidermis.

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

This study shows that Colorado Potato Beetle females actively avoid ovipositing on imidacloprid-treated plants, suggesting learned behavior contributes to their resistance and spread.

This study constructs and validates a phage-displayed macrocyclic peptide library using regioselective chemical reactions and identifies a potent SARS-CoV-2 neutralizing peptide through epitope-directed selection.

The paper couples a deformable microfluidic system with a fluidic dynamic model to study fluid-structure interaction in transient flow, showing the model predicts liquid displacement dynamics and identifies overshooting and oscillation phenomena relevant to dentine hypersensitivity.

The paper compares genomes of Paraburkholderia symbionts of Dictyostelium discoideum to identify adaptations supporting their role as professional symbionts.

This study investigates the divergent roles of FAMA in stomatal development across Brachypodium and Arabidopsis, revealing functional overlap and species-specific regulatory differences.

The paper investigates the impact of GR alleles on wheat root systems, finding that Rht-D1b increases seedling root size by enhancing cell length and meristem size, while Rht-B1b has no significant effect on root traits.

This study identifies Rho1 as a key regulator of egg size plasticity in honey bees, showing queens adjust egg size based on colony size through molecular changes involving energy metabolism and cytoskeleton functions.

The paper identifies a novel Y-shaped crosslink in SARS-CoV-2 MPro that acts as a redox switch, regulating its catalytic activity and offering new targets for antiviral drug development.

The paper presents a single-cell transcriptomic atlas of Macaca fascicularis, identifying cell interactions and disease associations.

A genetic screen in Arabidopsis identifies DDRM2, a multi-BRCT domain protein required for homologous recombination and regulated by SOG1.

This study investigates the role of GDF15 in APAP-induced liver injury in mice, finding no significant ameliorative effect from overexpression or supplementation of GDF15.

This paper describes the engineering of osmolality sensors called OzTracs by fusing fluorescent proteins to mechanosensitive ion channels, showing they report osmolality changes through indirect mechanisms.

This paper develops an mRNA vaccine targeting the Omicron variant's RBD, showing it induces Omicron-specific neutralizing antibodies but not against wildtype or Delta strains.

This study investigates the structural basis of SARS-CoV-2 Omicron variant's immune evasion and transmissibility using cryo-EM, revealing conformational changes and enhanced ACE2 binding.

This paper identifies that a P4 N-terminal carbamate in boceprevir-based inhibitors is crucial for high antiviral potency against SARS-CoV-2.

This study identifies O-tert-butyl-threonine at the P3 site as critical for enhancing cellular and antiviral potency of MPro inhibitors.

The paper measures DNA hybridisation rates of sequences without secondary structure and develops a model based on complementary nucleating interactions and sequence-dependent stability.

RNA2Immune is a database linking noncoding RNAs to immune functions, diseases, and vaccines, containing 50,433 experimentally supported associations across 42 species.

This study identifies FOXP4 as a regulator of beige adipocyte differentiation and thermogenesis, showing it suppresses thermogenic potential in preadipocytes but enhances it in mature adipocytes.