S. Zhao

This study shows hESCs-derived lung organoids can reconstruct human airway epithelium in vivo, with CD47high cells enhancing ciliated cell generation and epithelial thickness.

The paper analyzes canine cancer mutation rates across breeds and cancer types, finding a positive correlation with TP53 mutations and a breed-specific mutation signature in Golden Retrievers.

This study introduces a statistical method to analyze mutation dynamics in influenza A H3N2, showing regional mutation contributions to global epidemics and identifying key amino acids for therapeutic targets.

This paper develops a high-accuracy multiplexed SARS-CoV-2 antibody assay using a nano-plasmonic platform, showing high specificity and sensitivity in serum and saliva samples.

This study develops a non-infectious murine model to study SARS-CoV-2-induced ARDS and CSS, and identifies potential therapeutic agents that alleviate inflammatory symptoms.

This study investigates tree shrew susceptibility to SARS-CoV-2 infection and finds that they show mild symptoms and low viral replication, suggesting limited susceptibility.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

This study produces and tests an F(ab')2 fragment against SARS-CoV-2 RBD, showing potent in vitro neutralization with an EC50 of 0.07 g/ml.

The paper presents a molecular typing method for respiratory adenoviruses using universal PCR and sequencing primers for three capsid genes, enabling rapid identification of HAdV types and recombinants in clinical samples.

This paper describes the development of DN052, a novel TLR8 agonist with high potency and selectivity, showing strong antitumor activity and favorable safety profile, leading to phase I clinical trials.

This study shows that long-term veliparib treatment leads to chromatin-bound PARP1 and upregulation of inflammatory genes in BRCA1 mutant cells, but not in BRCA1-complemented cells.

This study estimates the basic reproduction number (R0) of 2019-nCoV in China during the early outbreak phase using exponential growth modeling and serial intervals from similar coronaviruses.

This study shows that Eco1-mediated acetylation promotes cohesin dimerization during S phase, which is regulated by Hos1 and Wpl1.

The paper characterizes the complete genome of a novel coronavirus, WHCV, linked to a respiratory outbreak in Wuhan, finding it closely related to SARS-like bat coronaviruses.

This study identifies a novel G protein-biased and subtype-selective agonist for the 5-HT2C receptor from herbal extracts, showing efficacy in weight loss similar to lorcaserin.

The paper identifies P5CS as a CTPS-interacting protein in Drosophila and shows they form cytoophidia, linking two enzymes in pyrimidine and proline biosynthesis.

This study examines testosterone level changes in female giant pandas during estrus and finds that testosterone peaks 4 days after estradiol peaks and is only correlated with estradiol after the estradiol peak.

This study shows N-acetyl cysteine (NAC) alleviates Coxsackievirus B-induced myocarditis by inhibiting caspase-1 and viral proteases, offering a potential therapeutic option.

This study uses single-cell RNA sequencing to analyze the origin of intra-tumoral heterogeneity in gastric cancer and identifies a prognostic gene signature.

This study compares the hypocholesterolemia effects of four probiotic strains with atorvastatin in a high-fat diet model, showing probiotics are less effective but alter gut microbiota differently.

The paper evaluates optimal fertilizer rates and planting density for soybean production in China using field experimental data, finding varying optimal rates for spring and summer soybean.

The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.

This study determines the structure of TRPV2 bound to cannabidiol, revealing a unique binding site and the role of the S4-S5 linker in channel gating.

This study identifies a conjugative MDR plasmid carrying the cfr(C) gene in florfenicol-resistant Campylobacter coli from cattle, conferring resistance to multiple antimicrobials including linezolid.

This paper evaluates AMRFinder, a tool for detecting antimicrobial resistance genes, against phenotypic data from 6,242 isolates, finding high consistency and improved accuracy over previous methods.

The paper examines bacterial transmission in gut and oral microbiomes of a closed cohort in Fiji, finding weak but significant transmission within households and between spouses using strain-level data.

This paper produces transgenic cassava with high amylose starch by silencing BE1 or BE2 genes, showing differences in starch properties between the two gene silencing lines.

This paper develops a heat-shock inducible CRISPR/Cas9 system in rice that enables controlled, heritable mutations with improved precision.

This study evaluates fusidic acid and its hydrogenation derivative for antimicrobial and anti-inflammatory effects against Gram-positive bacteria and in a mouse model.

This study tracks genetic adaptation of B. fragilis in individual human gut microbiomes over time, revealing persistent evolutionary dynamics and niche differentiation within a single host.