T. Yang

This study examines the temporal metabolic and transcriptomic changes in islets and liver of mice on high-fat diet, revealing dynamic pathophysiology and interorgan crosstalk in diabetes.

This study investigates WSSV infection in wild crustaceans in the Bohai Sea, finding high prevalence rates and confirming infection through electron microscopy.

The paper engineers reproductively isolated species using CRISPR to create threshold-dependent gene drive capabilities in D. melanogaster.

This study improves NADPH flux and xylitol production in engineered E. coli by dynamically controlling regulatory metabolites and metabolic pathways.

This study develops a virus-free live-cell visualization system for SARS-CoV-2 entry using a fluorescent spike trimer probe, enabling analysis of neutralizing antibodies and inhibitors.

This paper presents a chromosome-level genome assembly and annotation of Magnolia biondii, revealing insights into its evolutionary history and gene function.

This paper describes a rapid method using LAMP and Nanopore Flongle for detecting SARS-CoV-2 and other respiratory viruses in under two hours.

This study uses single-cell RNA sequencing to create a cell atlas of human ocular outflow tissues, identifying 12 cell types and mapping glaucoma-related gene expression.

This study shows that POMK phosphorylates core M3 to enable LARGE to elongate matriglycan on dystroglycan, preventing muscular dystrophy.

This study evaluates the use of CasRx, a Cas ribonuclease, for programmable RNA targeting in Drosophila melanogaster, showing transcript targeting, toxicity, and off-target effects.

The paper develops a high-affinity sPD-1 decoy molecule that neutralizes both PD-L1 and PD-L2, showing superior antitumor activity in ovarian cancer models compared to PD-1/PD-L1 antibodies.

This study identifies miR-574 as a regulator of FAM210A, which influences mitochondrial protein expression and cardiac remodeling in heart failure.

This study shows rutin inhibits biofilm formation in Staphylococcus xylosus by targeting the IGPD enzyme, reducing its activity and histidine synthesis.

The paper identifies haploidizer, a gene on a B chromosome in Nasonia vitripennis, that mediates genome elimination and sex conversion through testis-specific expression.

This paper identifies FvLcp1, a secreted type-D fungal LysM protein with chitin-binding domains, as a key factor in fumonisin production and host recognition in F. verticillioides during maize infection.

The paper analyzes the evolution of HIV-1 Env diversity across clades and regions, finding that inter-population diversity decreases while intra-population diversity increases due to conserved selective pressures.

This study shows cediranib inhibits Mycobacterium tuberculosis ClpP1P2 by targeting its equatorial handle domain, revealing conformational changes critical for its function and suggesting a strategy for species-specific inhibitors.

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.

The paper compares 3654 chloroplast genomes to uncover evolutionary patterns in green plants, identifying gene clusters and IR expansions.

This paper develops CRISPR-based split-gene drives in Aedes aegypti with high cleavage and transmission rates, demonstrating their potential for safe and reversible population control.

This paper evaluates the combination of artesunate and tetramethylpyrazine for treating experimental cerebral malaria, finding improved survival and neurological protection through proteomic analysis.

This study introduces SLHC-seq, a new targeted sequencing method that improves detection of pancreatic cancer by analyzing short mutant cfDNA fragments, enabling earlier diagnosis.

The paper reviews recent studies on bacterial glycogen as a durable energy reserve and presents a mathematical model to explain its role in bacterial persistence.

The paper assembles and describes the complete plastid genomes of four Brassicales species, finding they share a typical structure and phylogenetic consistency with prior studies.

This paper develops transgenic Cas9 lines in Aedes aegypti for efficient genome editing, enabling high-throughput gene disruption and potential gene drive applications.