W. C. Greene

Deep Phenotypic Analysis of Blood and Lymphoid T and NK Cells from HIV+ Controllers and Non-Controllers

This study compares T and NK cell phenotypes in blood and lymph nodes of HIV+ controllers and ART-treated individuals, finding distinct cellular features in lymphoid tissues.

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy

This study shows SARS-CoV-2 Spike protein causes abnormal blood clots and thromboinflammation, which are neutralized by a fibrin-targeting antibody.

mRNA vaccine-induced T cells respond identically to SARS-CoV-2 variants of concern but differ in longevity and homing properties depending on prior infection status

The CCL2 Chemokine Promotes Early Seeding of the Latent HIV Reservoir

This study shows that CCL2 chemokine promotes early HIV reservoir formation by recruiting CCR2/5+ CD4 T cells to sites of inflammation during acute infection.

The Atlas of the In Vivo HIV CD4 T Cell Reservoir

The paper develops a method to trace latently-infected HIV CD4 T cells to their original states using CyTOF, revealing the reservoir's conserved yet tissue-specific composition and enabling isolation of unstimulated latent cells.

SARS-CoV-2-specific T cells exhibit unique features reflecting robust helper function, lack of terminal differentiation, and high proliferative potential

The paper characterizes SARS-CoV-2-specific T cells in recovered patients, finding they exhibit robust helper function, reduced terminal differentiation, and high proliferative potential.

Chromatin Functional States Correlate with HIV Latency Reversal in Infected Primary CD4+ T Cells

The paper identifies that latency reversing agents reactivate less than 5% of latent HIV proviruses and shows distinct chromatin functional states between reactivated and non-reactivated cells.