W. Li

This study investigates how organic nitrogen inputs and associated microbial communities affect Microcystis growth and toxin production, showing that microbial interactions influence nitrogen availability and cyanotoxin levels.

This study identifies chlorhexidine and its derivative CM002 as clock activators with anti-adipogenic properties, showing they inhibit adipogenesis via Wnt pathway activation.

This study identifies the YY2/BUB3 axis as a regulator of SAC activity and shows how SAC hyperactivity and CIN levels influence tumor cell fate and drug sensitivity.

This study shows that human GM-CSF and IL-3 expression in humanized mice increases immune cell infiltration in HCC tumors, improving the model's resemblance to human disease.

This study shows colchicine stabilizes atherosclerotic plaques by converting harmful SMC-derived cells into protective myofibroblast-like cells, independent of its anti-inflammatory effects.

This study shows that FANA-R8-9 aptamer inhibits SARS-CoV-2 infection in human airway epithelium models and is stable and non-toxic.

This study identifies two novel oxysterol sulfates in zebrafish skin that function as alarm substances, inducing anti-predator behaviors and increasing cortisol levels at sub-nanomolar concentrations.

The paper investigates how lysosomes and endosomes interact with the ER through spatial regulation, revealing a mechanism involving actin cytoskeleton condensation and the VAP-STARD3-YWHAH pathway.

This study shows that regulatory T cells modulate basal somatic sensitivity in mice through enkephalin production, with Penk expression regulated by TNF receptor family and Batf.

This study examines immune responses in CoronaVac-vaccinated individuals after Omicron infection, showing enhanced antibody and cellular immunity compared to unvaccinated controls.

This study identifies METTL3-mediated stabilization of RRBP1 mRNA via m6A in prostate cancer and develops small-peptide inhibitors to target this pathway.

This study uses molecular dynamics simulations to analyze the structural and energetic aspects of cGAS-DNA oligomerization, revealing thermodynamic and kinetic barriers in low concentrations and favorable conditions for longer DNA.

This study analyzes genomes of Fusarium pseudograminearum strains to show that secondary metabolite synthesis genes influence their geographical distribution and toxin production.

This study identifies distinct microstructural and biomolecular features in ACL femoral and tibial entheses that contribute to their specific mechanical properties.

This study investigates how climate and biogeographic events influence diversification in Annonaceae, finding global temperature significantly impacts diversification rates and suggesting a shift from museum to recent cradle models.

The paper identifies ABHD17B as a therapeutic target for liver fibrosis by showing its depletion inactivates hepatic stellate cells and reduces fibrosis in mice.

This study identifies TILAM, a conserved lncRNA that promotes liver fibrosis by interacting with PML in HSCs, and shows its depletion reduces fibrosis in mouse models.

This study examines gut microbiome and serum metabolome changes in chronic low back pain patients with bone marrow lesions, identifying key microbial species and metabolic pathways involved.

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

This study uses multidimensional super-resolution microscopy to reveal nanoscale surface aggregates in aging FUS condensates and their impact on diffusion.

The paper shows that V-ATPase asymmetrically segregates the NuRD complex during cell division, influencing daughter cell survival or apoptosis through pH differences.

This paper uses GPT-4 to extract data from synthetic biology papers, creating structured datasets that improve ML predictions for yeast fermentation.

This study compares linear and SRV metrics for analyzing tumor cell shape heterogeneity, finding SRV provides better separation and low-dimensional representation of cell morphology.

This study uses deep learning to screen FDA-approved drugs and TCM compounds for anti-SARS-CoV-2 activity by targeting cell entry, identifying several effective candidates.

The paper characterizes a novel hormone receptor positive mammary adenocarcinoma model, MCa-P1362, showing stromal-cell interactions drive tumor growth, metastasis, and drug resistance.

The paper shows EGF enhances TNBC cells' response to CAP-activated medium by activating specific EGFR phospho-tyrosines and increasing ROS levels.

This study identifies tumor-specific neutrophils in glioblastoma that originate from meninges and contribute to immunosuppression, showing their role in tumor progression and poor prognosis.

This study identifies RasGAP and ZO-2 as essential for p190A RhoGAP's tumor suppressor function and Hippo signaling activation.

The paper analyzes transcript-error rates across diverse species, finding a narrow range and suggesting mechanisms for error purging, but the model explains only 20% of the variation.