Y. Chai

Artificial Intelligence-Enabled AlphaFold II Pipeline Guides Functional Fluorescence Labeling of Tubulin Across Species

The paper develops an AI-driven method to label tubulin isotypes in vivo across species, enabling precise visualization of microtubule dynamics and pathogenic variants without disrupting cellular processes.

When and how leachate toxicity of tire wear particles peaks: quantifying its dynamics using dose-response analysis

This study quantifies the temporal dynamics of leachate toxicity from tire wear particles using dose-response analysis, finding a biphasic pattern peaking at day 11.

Unlocking Herbal Potentials: Novel Shikimate Kinase Inhibitors in the Fight Against Antibiotic Resistance

This study identifies plant-derived Shikimate Kinase inhibitors from Goldenrod with antibacterial activity against Bacillus Subtilis, suggesting new antibiotic targets for combating antibiotic resistance.

Discovery of a novel MarR-type transcriptional regulator that controls cell death in Bacillus subtilis biofilms

The paper identifies YhjH as a MarR-type regulator that induces cell death in B. subtilis biofilms by modulating prophage genes and is renamed PcdR.

A Plant Flavonol Rescues a Pathogenic Mutation Associated with Kinesin in Neurons

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

Multigenerational effects of tire wear particle leachate through trophic transfer from producer to primary consumer

This study shows that TWP leachate ecotoxicity transfers from algae to rotifer through food chains and accumulates across generations, increasing ecological risk.

Vacuolar H+-ATPase Determines Daughter Cell Fates through Asymmetric Segregation of the Nucleosome Remodeling and Deacetylase Complex

The paper shows that V-ATPase asymmetrically segregates the NuRD complex during cell division, influencing daughter cell survival or apoptosis through pH differences.

RecA levels modulate biofilm development in Acinetobacter baumannii

This study shows that varying RecA levels in Acinetobacter baumannii affect biofilm formation and dispersal through the regulator bfmR, highlighting the role of DDR in infection persistence.

Identification of cytokine predominant immunosuppressive class and prognostic risk signatures in glioma

The paper identifies an immunosuppressive class of glioblastoma (IDC) with high anti-inflammatory cytokine expression and poor prognosis, suggesting resistance to immune checkpoint blockade therapy.

Carryover effects of tire wear particle leachate threats reproduction across multiple generations

This study shows that exposure to tire wear particle leachate across multiple generations impairs reproduction in rotifers, leading to population collapse.

De novo design of site-specific protein interactions with learned surface fingerprints

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

Spatiotemporal landscape of SARS-CoV-2 pulmonary infection reveals Slamf9+Spp1+ macrophages promoting viral clearance and inflammation resolution

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection

This study investigates antibody evasion by SARS-CoV-2 Omicron sublineages BA.2.12.1, BA.4, and BA.5 against plasma from vaccination and BA.1 infection, showing increased neutralization escape.

Minor differences in peptide presentation between chicken MHC class I molecules can explain differences in disease susceptibility

The paper shows that differences in peptide binding between chicken MHC class I alleles BF2*1901 and BF2*1501 explain their differing susceptibility to Mareks disease.

Controllable drug release of pH-sensitive liposomes encapsulating artificial cytosol system

This paper develops an artificial cytosol system using agarose-sucrose to create pH-sensitive liposomes that enhance drug delivery efficiency.

Bacterial galactosemia is caused by cytoplasmic interference of an essential cell wall biosynthesis glycosyltransferase

This study identifies the mechanism of bacterial galactosemia, showing that galactose interferes with MurG, an essential glycosyltransferase, leading to cell wall biosynthesis inhibition and cell death.

Insights into the diversity and survival strategies of soil bacterial isolates from the Atacama Desert

This study isolates and characterizes 74 bacterial strains from Atacama Desert soil, revealing their pigmentation, biofilm formation, antibiotic production, and resistance, highlighting survival strategies in extreme environments.

Negative interplay between biofilm formation and competence in the environmental strains of Bacillus subtilis

This study shows that robust biofilm formation in environmental Bacillus subtilis strains reduces competent cell rates through cross-pathway regulation between biofilm and competence systems.

Sclerotinia sclerotiorum hijacks copper from its host for infection

This study identifies copper hijacking by Sclerotinia sclerotiorum during infection and shows host resistance mechanisms involving copper homeostasis.

Decreasing Serine Levels During Growth Transition Triggers Biofilm Formation in Bacillus subtilis

This study shows that decreasing serine levels during growth transition triggers biofilm formation in Bacillus subtilis by causing ribosome pausing on specific serine codons, leading to reduced sinR translation and biofilm induction.