W. Liu

This study identifies IDH2 as a targetable regulator of drug resistance in CML by analyzing proteomic changes in resistant K562 cells.

This study identifies DDX21 cleavage by caspase-3/6 during virus infection as a mechanism to suppress IFN-β signaling by disrupting the DDX1-DDX21-DHX36 complex.

This study develops a trimeric RBD vaccine that induces long-term immunity and complete protection against SARS-CoV-2 in nonhuman primates.

This study uses fMOST and scRNA-seq to map the spatial and cellular distribution of rabies virus in the mouse brain, revealing infection in multiple nuclei and non-neuronal cells.

This study uses single-molecule FRET to show that NF-κB exhibits a continuum of binding modes that control its association and dissociation from DNA, with IκB modulating these dynamics.

This study shows that IBV uses nsp15 to inhibit stress granule formation, thereby evading antiviral responses and promoting viral replication.

The paper assembles a chromosome-scale, allele-aware autotetraploid genome of alfalfa cultivar Zhongmu-4 and identifies 101 SNPs associated with 27 agronomic traits using GWAS.

This study inhibits multi-species biofilm formation by targeting cellular metabolism with three metabolic inhibitors, showing enhanced efficacy when used together.

This study analyzes the evolutionary patterns of ACE2 binding affinity to SARS-CoV-2 spike protein across 247 vertebrates and identifies key amino acid mutations driving affinity divergence.

This study engineers 'spark-cell' spheroids to enable optical pacing of cardiac tissue, showing they can stimulate human stem-cell-derived cardiomyocytes faster than direct genetic modification.

This study shows Ythdc1, an m6A reader, regulates LINE1 scaffold function in mouse ESCs, affecting self-renewal and differentiation through chromatin interactions.

This study shows that Newcastle disease virus induces ferroptosis in tumor cells via the p53-SLC7A11-GPX4 pathway, leading to nutrient deprivation and cell death.

This study characterizes the dynamic changes in B-cell receptor repertoires of COVID-19 patients using next-generation sequencing, revealing clonotype overlap, lineage expansion, and V gene usage patterns.

This paper investigates the catalytic mechanism of SznF, revealing an unusual N-nitrosation pathway involving electron shuttling without high-valent iron species.

This study shows Mer2 phase separation forms droplet-loop chromatin structures to enable diverse meiotic DSB formation.

This study shows ORMDL1 is upregulated in colorectal cancer and associated with better patient survival.

This paper develops data-informed strategies to design hydrolytic nanozymes with enhanced catalytic activity and broad substrate specificity.

This paper identifies a shared trans flavin-dependent assembly line for 2,2-bipyridine formation in caerulomycin and collismycin antibiotics, revealing sulfur fate differentiation through differential sulfhydryl group treatment.

This study shows that loss of Tmem30a in podocytes causes albuminuria and glomerulosclerosis in mice, with reduced TMEM30A expression observed in human podocytopathies.

This paper identifies a cyclic phosphoramidate prodrug that shows anti-dengue activity in vitro and in vivo but is suspended due to toxicity concerns.

The paper identifies a metabolic coincidence mechanism in Arabidopsis that controls winter photoperiodism, independent of the canonical CO/FT pathway.

This study investigates the dynamic conformational equilibrium of the dengue virus NS3pro-NS2B complex and shows that proteolytic activity correlates with the population of the closed conformation.

This study identifies a viral protein translation mechanism involving mitochondrial machinery and highlights mitochondria as a target for antiviral drug development.

The paper investigates the ftin gene's role in wheat under cold stress, finding it inhibits spike development through multiple pathways and phenotypic changes.

This study shows that inhibiting FATP2 in MDSCs reduces ROS and enhances anti-PD-L1 immunotherapy by improving T-cell function and reducing PD-L1 expression.

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

This paper reports an AviCys formation pathway in thioviridamide non-lanthipeptides that does not require lanthionine synthetase activity.

This study identifies miR-1 as a conserved microRNA in ticks that prolongs engorgement time and is differentially expressed across developmental stages.

This study develops a cell-based chimeric vaccine against SARS-CoV-2 that induces strong T cell immunity and neutralizing antibodies without toxicity.

Virus-antibody coevolution in rhesus macaques recapitulates developmental features of human antibodies.