W. Wu

This study identifies two broadly neutralizing antibodies against SARS-CoV-2 variants and shows their synergistic neutralization effect, supported by cryo-EM structures.

The paper identifies vascular stem cells (VSCs) as a novel target for treating chronic vein graft failure by promoting intimal hyperplasia through paracrine signaling.

The paper examines intraspecies diversity and evolutionary patterns of microbial populations in deep sea cold seep sediments, finding depth-dependent diversification and purifying selection on key metabolic genes.

The paper identifies a collagen glucosyltransferase in Acanthamoeba Polyphaga Mimivirus through genomic and structural analysis, revealing its unique enzymatic activity and substrate specificity.

This study identifies RipAF1 as an effector that ADP-ribosylates host FBN1, inducing resistance against bacterial wilt by disrupting disease signaling.

The paper shows that osmotic stress induces stress granule formation in Drosophila S2 cells, modulated by calmodulin and calcium signaling, distinct from Sec body formation.

This study identifies that the co-deletion of CIC and ERF leads to ETV1 activation, driving prostate cancer progression without fusion events.

This study identifies BOS1 as a positive regulator of wounding-induced cell death and plant susceptibility to Botrytis cinerea, showing its role in both fertility and disease response.

The paper shows that nuclear spatial organization, particularly near spindle-pole bodies, influences centromere identity by facilitating CENP-ACnp1 incorporation.

This study identifies changes in small non-coding RNAs (sncRNAs) in SARS-CoV-2 infection, showing that tRFs and a viral-derived sncRNA (sv-CoV2-346) are significantly altered.

This study generates SARS-CoV-2 virus-like particles using baculovirus expression, showing they induce neutralizing antibodies and protect against variant challenge in a hamster model.

This paper develops a portable 3D microfluidic chip for rapid single-cell antibiotic susceptibility testing and bacterial quantification, showing improved speed, sensitivity, and accuracy compared to traditional methods.

This study shows that mice with permanently farnesylated prelamin A live nearly normal lifespans but show aging-related defects, suggesting prelamin A accumulation contributes to aging phenotypes.

This study identifies a FAK-YAP signaling axis that drives drug-tolerant persister cells and residual disease in lung cancer, showing that inhibiting this axis improves tumor response to targeted therapies.

The paper tracks tumor evolution in a mouse model using lineage tracing and single-cell RNA-seq, revealing plasticity, fitness-associated programs, and stereotypical evolutionary trajectories.

This paper reports the preclinical efficacy of ALD-R491, a vimentin-targeting compound, in treating COVID-19 by reducing viral entry, enhancing pathogen clearance, and suppressing overreactive immune responses.

This study investigates the cellular localization and cytoskeleton interactions of reflectin proteins, revealing their localization preferences and potential mechanisms for nuclear entry and cytoskeletal binding.

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

This study identifies a lineage of antibodies from infected rhesus macaques that neutralize 54% of HIV-1 strains by expanding the antibody-Env interface around the V2 loop.

This paper develops a novel PROTAC, ZL216, using an aptamer as a targeting ligand to selectively degrade nucleolin in breast cancer cells, inhibiting their proliferation and migration.

This paper develops an adaptive optics three-photon microscope for high-resolution imaging in deep brain tissue, achieving near-diffraction-limited performance and enabling functional calcium imaging and microsurgery through the intact skull.

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

The paper identifies non-reproducible antibody-antigen interactions in clinical sera and develops a model to explain them, improving serological testing for viral infections like COVID-19.

This study identifies two antibodies, F61 and H121, that neutralize SARS-CoV-2 and its variants, including B.1.1.7 and B.1.351, by targeting distinct epitopes on the RBD.

This study analyzes rhizosphere bacterial diversity of Angelica dahurica var. formosana across different sites and varieties, finding stable communities and key taxa linked to yield and quality.

The paper describes the Forget-Me-Not dHCP study, which acquires high-resolution diffusion MRI data from unfixed post-mortem neonatal brains and presents preliminary analyses of cortical and white matter structures.

This paper introduces MLC-Seq, a method to sequence full-length tRNA isoforms and quantify RNA modifications, demonstrating its application on yeast and mouse tRNAs.

Conditional Tfr1 ablation in satellite cells causes ferroptosis, leading to skeletal muscle regeneration defects and labile iron accumulation, recapitulated in aged rodents.