X. Hu

The paper develops a microfluidic droplet array for high-throughput screening of lipid-producing microalgae, enabling real-time monitoring and identification of individual cells under different conditions.

This study identifies FoxP3-mediated inhibition of RyR2 as a mechanism by which regulatory T cells suppress immune responses through reduced calcium signaling and impaired T cell-DC interactions.

This study identifies RipAF1 as an effector that ADP-ribosylates host FBN1, inducing resistance against bacterial wilt by disrupting disease signaling.

This paper introduces DeepCAD-RT, a real-time denoising method for fluorescence time-lapse imaging that improves signal-to-noise ratio with fewer photons, demonstrated across multiple organisms and biological processes.

This paper develops hetero-bivalent nanobodies that neutralize multiple SARS-CoV-2 variants, including Omicron, and show protective effects in vivo.

This study identifies the wheat gene TaD11-2A, which regulates grain size and root length, and shows its favorable haplotype improves grain yields and salt tolerance in wheat.

This study shows KMT2C deficiency increases APOBEC mutagenesis and genomic instability in multiple cancers by impairing DNA replication and promoting APOBEC activity.

This study identifies FAM84B amplification as a marker of poor prognosis in ESCC and shows it promotes cell proliferation by interacting with NPM1 to suppress CDKN2A.

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

This study identifies ERK7 and CSAR1 as critical for apical complex stability in Toxoplasma gondii, showing CSAR1's role in maternal cytoskeleton turnover and its mislocalization affecting parasite replication.

This study shows that PDF2, an HD-Zip IV TF, binds lysophosphatidylcholines via its START domain and regulates phospholipid metabolism in response to phosphate availability.

This study shows that CD47 cross-dressing via extracellular vesicles inhibits phagocytosis without causing cell death, offering a safer alternative to CD47 overexpression.

This study identifies how self-association of TIR domains in plant NLRs configures the NAD+-binding site, linking it to NADase activity and signaling.

This study compares DNA and DNA+protein vaccines in rhesus macaques, finding that co-immunization with both induces stronger antibody responses and better control of SARS-CoV-2 infection.

This study develops a bottom-up nanofabrication strategy to control integrin ligand assembly, enabling tunable suppression of cancer cell migration through precise ligand density modulation.

This study shows that lipocalin 2 promotes inflammatory breast cancer aggressiveness and skin invasion by enhancing proliferation, migration, and metastasis.

This study identifies endothelial MEKK3 as a regulator of inward arterial remodeling through TGFβ-Smad2/3 signaling, leading to hypertension and atherosclerosis.

BAM15 reduces sepsis mortality and kidney damage in mice by decreasing mitochondrial DNA and reactive oxygen species.

This study shows ARID1A loss activates HERVH, which promotes tumor growth by modulating BRD4-dependent transcription in colorectal cancer.

This study identifies two molecular subtypes of gastric cancer using multi-omics data and clustering algorithms, showing distinct survival outcomes and therapeutic responses.

The paper uses a hybrid in silico approach combining machine learning and pharmacophore modeling on NCATS screening data to identify novel inhibitors effective against multiple SARS-CoV-2 variants.

This study shows a single-dose AAV-based vaccine induces long-lasting neutralizing antibodies against multiple SARS-CoV-2 variants in rhesus macaques.

This paper develops and characterizes SARS-CoV-2 RBD-specific alpaca nanobodies, showing improved binding affinity and neutralizing potency through bivalent engineering.

This study uses single-cell transcriptomics to show hyperinsulinemia affects pancreatic cancer development and immune microenvironment by altering immune cell pathways and reducing pre-cancerous lesions.

This study shows that two rice pests, the brown planthopper and the rice striped stem borer, cooperate by jointly attacking rice plants, improving plant quality and reducing parasitism risk.

This study uses single-cell RNA sequencing to analyze aging-related changes in subcutaneous adipose tissue, revealing shifts in cellular roles and metabolic phenotypes associated with aging.

This study shows that energy expenditure during cell spreading on stiff substrates affects stem cell responses to matrix stiffness via AMPK activation.

This study evaluates SARS-CoV-2 entry mediated by ACE2 from 11 species, finding that pangolin and some mammals allow entry, while others do not, suggesting complex cross-species transmission potential.

This study identifies multiple HIV-1 escape mechanisms from PGT135 in a slow progressor, highlighting the role of glycan sites and V1/V4/C2 region changes in antibody resistance.