X. Hu

This study shows that honeybee gut microbiota influences olfactory learning, brain neurotransmitter levels, and metabolism, with parallels to human autism-related gene expression.

This study shows that honeybee genetics influence gut microbiota composition and strain-level diversity through social transmission, revealing a gut-brain connection.

The paper identifies a CD127-expressing monocyte subset, M127, associated with anti-inflammatory properties in inflammatory diseases and correlates its expansion with milder COVID-19 outcomes.

This study identifies immune mechanisms underlying CyHV-3 resistance in a common carp strain through transcriptomic analysis of gene and lncRNA expression.

This study shows that deleting the insulin receptor in beta-cells improves glucose tolerance in some mice but not others, depending on age and diet.

This paper uses CRISPR to enhance browning of human adipocytes, improving metabolic health in mice without immunogenic Cas9 exposure.

This study identifies cadherin-11 as a mediator of cancer cell hijacking of fibroblasts post-EMT, enhancing invasion and metastasis in solid tumors.

The paper identifies 319 compounds with anti-SARS-CoV-2 activities through a high-throughput screen, including 91 approved drugs and 49 investigational drugs, with 230 compounds previously unreported.

This paper investigates the unwinding mechanism of coronavirus nsp13 helicases using single-molecule FRET, revealing distinct step sizes and NTP hydrolysis patterns between MERS-CoV and SARS-CoV-2 nsp13.

The paper identifies 9240 lncRNAs in diploid cotton using multi-omics data and reveals their transcriptional regulation and co-expression with protein-coding genes and GWAS SNPs.

This study identifies 23 SARS-CoV-2 3CLpro inhibitors through high-throughput screening, with several showing potent activity against viral infection.

This study identifies decorin as a negative regulator of E-cadherin in inflammatory breast cancer, showing it reduces migration, invasion, and metastasis by destabilizing E-cadherin and inhibiting EGFR/ERK signaling.

This study tracks the dynamic localization of Japanese encephalitis virus (JEV) in mouse brain nuclei over time, revealing its progression from thalamus and medulla oblongata to widespread distribution in the central nervous system.

The paper uses scRNA-seq to compare ACE2 expression and bladder cell clusters in OAB and healthy mice, finding reduced umbrella cells and higher ACE2 in epithelial cells, suggesting altered 2019-nCoV infection pathways.

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

This study reports the largest sequenced plant genome, Paris polyphylla var. yunnanensis, and identifies genes involved in polyphyllin biosynthesis.

The paper identifies six autophagy modulators that block SARS-CoV-2 cytopathic effects in Vero-E6 cells with EC50 values between 2.0 and 13 µM.

This study identifies MAPK2 as essential for Toxoplasma gondii cell division by regulating centrosome duplication, leading to parasite death when MAPK2 is lost.

The paper reports the structure of SARS-CoV-2 main protease in the apo state at physiological pH, revealing its inactive conformation and structural differences from the active state.

This study identifies a vertically transmitted core virome in Aedes albopictus mosquitoes across developmental stages and continents, and finds a novel virus related to Yongsan bunyavirus 1.

This paper develops a PROTAC molecule, BT1, that selectively degrades BCR-ABL over c-ABL in leukemia cells using nimbolide as an E3 ligase recruiter, showing additional anti-proliferative effects.

This study characterizes the negative effects of corn stover hydrolysate on industrial S. cerevisiae and identifies transcriptomic responses during the lag phase.

The paper identifies CAG promoter activity as a marker for reprogramming-efficient cells and shows its association with MKL1/SRF activity and cell cycle dynamics.

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

The paper identifies ERK7 as essential for conoid assembly in Toxoplasma gondii, causing severe defects in parasite motility and invasion.

This study uses molecular dynamics simulations to investigate how magnesium ions bind to and modulate the μ-opioid receptor, revealing their role in stabilizing the activated state and enhancing opioid efficacy.

This study identifies a P. infestans miRNA that targets a potato gene, promoting late blight disease by modulating host mRNA expression.

This paper introduces an automated data labeling neural network for real-time hand motion prediction from sEMG signals, achieving high accuracy and early response with no need for manual motion labeling.

The paper introduces a fluorescent reporter to measure cell cycle speed in single cells using one snapshot, demonstrating its application in hematopoietic cells and solid tissues.

The paper examines non-genetic intra-tumor heterogeneity in lung tumors, finding it significantly influences phenotypic diversity and evolutionary dynamics beyond genetic factors.