X. Hu

This study shows that loss of the ATRX/DAXX complex disrupts rDNA heterochromatinization, leading to increased rDNA transcription and promoting glioma development.

This study overexpresses Arabidopsis ATLP1 in potato to enhance resistance against early and late blights, showing significant reductions in disease progression and symptom severity.

This study identifies nimbolide's mechanism of action by showing it targets RNF114, leading to stabilization of p21 and inhibition of breast cancer cell proliferation.

This study surveys Chinese university students to examine gender differences in attitudes toward death, finding significant differences that persist after controlling for other factors.

This study characterizes and repurposes the endogenous Type I-F CRISPR-Cas system of Zymomonas mobilis to create an efficient genome engineering toolkit with 100% efficiency in various genetic modifications.

The paper shows that siRNA with a 5-nucleotide motif suppresses DNA-mediated IFN and cytokine signaling by inhibiting IFI16-DNA binding.

This study identifies parthenolide's covalent targeting of FAK1 in breast cancer cells, showing inhibition of FAK1-dependent pathways and cancer cell proliferation.

This study evaluates genomic selection effectiveness for winter wheat improvement by assessing prediction accuracy and response to selection across different environmental conditions.

This study shows that fast-cycling granulocyte-macrophage progenitors are more likely to transform into leukemia when expressing the MLL-AF9 oncogene.

This study shows that low-dose cadmium exposure in mice increases lung inflammation and genetic responses to H1N1 influenza virus infection.

The paper shows that LC3 and STRAP regulate JMY's actin assembly during autophagy, with LC3 activating JMY and STRAP inhibiting it.

This study identifies KDM4D as a key regulator of hepatic fibrosis by modulating TLR4 signaling through histone demethylation in HSCs.

This study shows TP, activated by Twist1, promotes HCC metastasis and VM via pentose Warburg effect by linking pentose phosphate pathway and glycolysis.

This study shows lactate dehydrogenases (LDHA and LDHB) can both generate and prevent reactive oxygen species (ROS) in cancer cells, depending on oxidative stress levels.

This study develops CRISPR delivery particles (CriPs) for efficient gene editing in cultured cells and in vivo, demonstrating their potential for therapeutic applications in metabolic disease.

This study shows that β-lactam antibiotics increase MRSA pathogenicity by upregulating the tlpps gene cluster via SarA, leading to enhanced inflammation and infection severity.

This paper introduces RosettaAntibodyDesign (RAbD), a computational framework for antibody design that improves affinity by redesigning CDRs using structural and sequence-based methods.

This study shows that trehalose and Hsp12 synergize to protect yeast from desiccation by stabilizing proteins and remodeling membranes.

The paper investigates how vegetative compatibility groups (VCGs) influence virulence of Verticillium dahliae on strawberry, finding that VCGs are strongly related to virulence levels and that VdAve1-containing isolates show higher early virulence.

This study identifies USP11 as a deubiquitylase that stabilizes p21, affecting cell cycle progression and DNA damage responses.

The paper reports cancer-associated transcript fusions in 33 tumor types using TCGA data and provides a resource for accessing the results.

This study investigates vancomycin's interaction with lipid vesicles, showing it binds to head groups and affinity increases with vesicle size and preference for phosphatidylglycerol.