X. Shen

This study shows that maternal exposure to dibutyl phthalate during pregnancy and lactation leads to increased visceral obesity in adult female offspring without affecting serum glucolipid levels or the PI3K/AKT pathway in muscle.

This study identifies CycK:CDK13 as a kinase complex that phosphorylates SERINC5 at S360, enhancing Nef-mediated downregulation and counteracting its antiviral activity.

This paper identifies putative critical quality attributes (CQAs) for mesenchymal stem/stromal cells (MSCs) using multi-omics data and PLSR modeling to predict functional capacity.

A broadly neutralizing antibody protects against multiple SARS-CoV and SARS-CoV-2 variants in mice by targeting a conserved epitope in the receptor-binding domain.

This study identifies that SARS-CoV-2 nucleocapsid protein undergoes phase separation, which can be modulated by small molecules, offering new therapeutic strategies against COVID-19.

The paper investigates how RNA-binding proteins (RBPs) influence RNA polymerase II activity through phase separation, showing that RBPs like PSPC1 enhance polymerase engagement and transcription.

This study evaluates adjuvants for a subunit SARS-CoV-2 nanoparticle vaccine in non-human primates, showing durable neutralizing antibody responses and protection against infection.

This study shows that B.1.1.7 SARS-CoV-2 variant remains neutralizable by antibodies from ancestral Spike vaccines and convalescent sera, though with reduced efficacy.

The paper examines sex differences in MAIT cell responses in COVID-19 patients, finding reduced circulating MAIT cells in females and a protective gene signature associated with female MAIT cells.

This paper assesses the importance of recovery actions in reducing extinction risk for threatened species under the new Global Biodiversity Framework.

The paper presents cryo-EM structures of glycan cap antibodies that neutralize ebolavirus by targeting a conserved MLD-anchor site, revealing common features among broadly neutralizing antibodies.

This study shows the SARS-CoV-2 envelope protein causes ARDS-like damage and identifies channel inhibitors as potential antiviral targets.

This paper introduces a fast 23Na-MRSI technique for mapping sodium T2* relaxation and absolute concentration in skeletal muscles with high reliability.

This study evaluates an SIV-based IDLV vaccine expressing sequential CH505 Envs in rhesus macaques, showing improved antibody responses and virus control but no broadly neutralizing antibodies.

This study investigates the PK/PD relationship of tilmicosin against M. hyopneumoniae, identifies resistance mechanisms, and suggests optimal dosing regimens.

This study isolates and characterizes a coronavirus from Malayan pangolins that is highly similar to 2019-nCoV, suggesting pangolins may act as an intermediate host.

The paper identifies two distinct mechanisms by which small molecules inhibit LpxA acyltransferase, a key enzyme in lipopolysaccharide biosynthesis.

This study identifies two small-molecule inhibitors of LpxA, revealing distinct inhibition mechanisms and highlighting compound 2's improved properties for antibacterial development.

This study identifies C17orf53 as a novel gene involved in inter-strand crosslink repair, showing its role in DNA replication and repair factor loading.

This study evaluates the mutant selection window and killing effects of five antibiotics against Mycoplasma hyopneumoniae, finding that danofloxacin, tylosin, and doxycycline are more likely to promote resistance than tiamulin and valnemulin.

This study shows that aversive learning improves episodic memory for reinforced stimuli in both adolescents and adults.

The paper investigates the role of endogenous polyamines and associated genes in paraquat resistance in goosegrass, finding that spermidine levels and specific genes correlate with resistance.

The paper examines codon substitution rates across species and finds that evolutionary rates are strongly negatively correlated with amino acid distance under predominant negative selection.

This study compares HIV-specific antibody kinetics in infant and adult rhesus macaques infected with SHIV, finding similar antibody responses despite differences in Tfh and germinal center B cell dynamics.

This study measures heavy metal levels in soil, water, forages, and tissues of sheep and humans near a zinc smelter, finding elevated cadmium and lead concentrations linked to health risks.

This study compares the nuclear export and cargo dissociation mechanisms of RanBP1 in fungi and animals, revealing distinct interactions and complex stoichiometry.

This study shows that intestinal crypts rapidly recover from focal damage through coordinated stem cell motion, which is impaired by aging.

The paper studies mutational meltdown in HeLa cancer cell populations, finding high rates of deleterious copy number variations and significant fitness reduction per mutation.

This study shows estrogen protects against intervertebral disc degeneration by upregulating ER, but miR-221 reduces this protection by targeting ER.