X. Zhang

RapidAIM 2.0 evaluates gut microbiome functional responses to xenobiotics using high-throughput metaproteomics and in vitro culturing.

This study identifies molecular differences between p110γ-p84 and p110γ-p101 complexes that explain their differential activation by GPCRs and Ras.

This paper uses a 3D human atrial myocyte model to study how changes in Ca2+-handling proteins and TATS density affect arrhythmia mechanisms in disease.

This study develops a 3D human atrial myocyte model to investigate how variations in transverse-axial tubule systems (TATS) affect Ca2+ handling and promote arrhythmia through spontaneous Ca2+ release.

This study identifies NCgl0254 and NCgl0255 as novel O_SCPLOWLC_SCPLOW-serine exporters in C. glutamicum and shows that all four exporters (ThrE, SerE, NCgl0254, NCgl0255) are interdependent in O_SCPLOWLC_SCPLOW-serine export, with SerE being the major contributor.

This study identifies aCcr1, an archaeal transcription factor, and its viral homologs as regulators of cell cycle progression, showing they control cell division by repressing cdvA expression.

This study shows metformin lowers IOP and protects trabecular meshwork from oxidative damage by activating integrin/ROCK signaling in both in vivo and in vitro models.

This study shows that tumor-educated monocytes suppress T cells via adenosine and that depleting adenosine with PEG-ADA enhances immunotherapy response in preclinical models.

This study identifies RHAMM as a marker of invasive niches in breast cancer, showing its association with poor outcomes and promoting invasion through a 27-gene signature.

The paper identifies a regulatory mechanism linking drought stress and fiber yield in upland cotton through the interaction of GhHSFA6B-D and GhIPS1-A, showing conservation in Arabidopsis.

This study investigates the adhesion of SARS-CoV-2 S proteins from different variants to human ACE2 using single-molecule and single-cell force spectroscopy, finding Delta variant has the highest binding affinity.

This study shows that ZF-tMeCP2, a cell-penetrant MeCP2 variant, can deliver to the nucleus and repress transcription from methylated promoters, suggesting a potential therapeutic strategy for Rett syndrome.

The paper develops bacterial Vm sensors to study Vm dynamics and shows that excitable states enhance antibiotic tolerance.

The paper shows that plant defense elicitors induce amino acid accumulation, which directly suppresses bacterial virulence and growth.

This paper develops an automated machine learning pipeline for differential cell counts on whole-slide bone marrow aspirate smears, showing high concordance with manual counts and reduced intra-slide variance.

This study identifies a cooperative interaction between HAND2 and MYCN in neuroblastoma that regulates enhancer binding and gene transcription, and shows that targeting these factors suppresses tumor growth.

This study demonstrates that nuclear sAC-mediated cAMP synthesis is necessary and sufficient for cAMP-dependent cell proliferation, independent of cytosolic cAMP levels.

MaLAdapt identifies novel adaptive introgression loci from Neanderthals and Denisovans in non-African populations using machine learning.

The paper uses proximity labeling and proteomics to identify proteins interacting with emerin and LBR at the inner nuclear membrane, revealing shared and distinct partners.

This study uses FIB-SEM to analyze 3D organelle structures in Chlorella pyrenoidosa during growth stages, revealing changes in mitochondria, chloroplasts, and starch grains.

This study shows Orai1 and Orai3 are essential for CRAC channel function and metabolic reprogramming in B cells, impacting proliferation, survival, and metabolic processes.

The paper identifies over 6,000 transcription factor binding sites (TFBSs) under accelerated evolution in primates, suggesting their role in neurodevelopmental divergence.

The paper develops an ex vivo 3D microtissue model of MPNST that captures genomic diversity and predicts in vivo drug response.

This paper develops a computational framework to simulate human atrial electrophysiology and Ca2+-handling, revealing synergistic PKA and CaMKII signaling as key drivers of atrial arrhythmogenesis.

This study identifies PKC as a key driver of tumorigenic transcriptional networks in prostate cancer by showing its role in cell cycle, EMT, and immune checkpoint regulation.

This paper develops aminoadamantane nitrate compounds that inhibit SARS-CoV-2 infection by S-nitrosylating ACE2 and blocking viral entry, showing efficacy in vitro and in a Syrian hamster model.

The paper introduces PanGu Drug Model, a deep learning architecture for drug discovery that achieves state-of-the-art results in molecule property prediction, generation, and optimization.

This study shows that m6A RNA methylation reduces gene expression variability and impairs reproductive thermotolerance in Arabidopsis under heat stress.

This study identifies key genes regulating mesophyll conductance in drought-resistant rice under severe drought by comparing gene expression and photosynthetic processes between two rice cultivars.

This study reports the cryo-EM structure of the wheat CNL Sr35 resistosome and shows its structural and functional conservation with the Arabidopsis ZAR1 resistosome.