X. Zhang

This study identifies MDF as a splicing factor regulating root meristem function in Arabidopsis by controlling splicing of RSZ33, ACC1, and SR34, balancing stemness and stress response.

This study identifies distinct dopamine neuron functions in Drosophila that drive attraction and aversion during olfactory memory formation, showing separate roles for dopamine, glutamate, and octopamine.

This study identifies regulators of wheat spike development through multi-omic analysis and GWAS, revealing novel transcription factors that influence spike architecture and flowering time.

This study compares the immune response in diffuse midline glioma after FLASH and conventional radiation using single-cell RNA sequencing and flow cytometry, finding differences in type 1 interferon signaling over time.

The paper measures the bending stiffness of the bacterial flagellar hook under counterclockwise and clockwise rotations, finding it doubles under clockwise rotation.

The paper evaluates HIV-1 vaccine candidates using HCDR3-engineered B cells, finding that SOSIP-TM mRNA-lipid nanoparticles induce stronger anti-apex responses than multimerized SOSIP proteins.

The paper reports atomic structures of human spliceosome complexes to elucidate PRP5's role in branch site proofreading during pre-mRNA splicing.

This study shows PSKR1 in Arabidopsis balances growth and defense responses to maintain beneficial rhizosphere microbiome interactions.

This study evaluates antibody kinetics and durability after CoronaVac vaccination in health subjects, finding waning antibody levels over time and improved responses with a booster dose.

The paper designs and engineers a high-yield, efficient recombinant peptide asparaginyl ligase (PAL) by modifying a consensus legumain sequence and applying the LAD hypothesis.

This study identifies oral microbiome dysbiosis as a non-invasive biomarker for detecting community-acquired pneumonia.

This study determines the structure of S. aureus GpsB's N-terminal domain, revealing its interaction with FtsZ and PBP4, and shows its essential role in cell division.

This study identifies genomic signatures of convergent adaptation to high altitudes in alpine plants by analyzing reference genomes and gene expression profiles.

This study identifies distinct molecular mechanisms for proactive and retroactive interference in Drosophila during consecutive learning tasks.

This study evaluates RosettaLigand's ability to predict low-affinity ligand binding in fragment-based drug discovery using NMR data and finds it ranks binders with an AUC of 0.74.

This study identifies tissue-specific metabolic reprogramming in sepsis, showing that mitochondrial adaptations in vital organs, not global dysfunction, underlie sepsis tolerance.

This study shows Treg cells drive MYCN-mediated immunosuppression and tumor aggressiveness in high-risk neuroblastoma using human and zebrafish models.

This study shows that enteroendocrine cells regulate crypt metabolism and intestinal stem cell function by transmitting nutrient status to the stem cell niche.

This study identifies a transcriptional network involving var2csa that coordinates var gene switching in malaria parasites, explaining how they maintain chronic infections by limiting antigen exposure.

The paper identifies conserved glycine residues as key determinants distinguishing peptide asparaginyl ligases (PALs) from asparaginyl endopeptidases (AEPs) in plant legumains.

The paper introduces HOPE-SIM, a cryo-CLEM system that improves targeting precision for cryo-ET by integrating 3D SIM and software, achieving 150 nm correlation accuracy.

This paper develops an in-silico labeling method using a generative adversarial network to predict fluorescent images from brightfield images, enabling kinetic myelination assays.

This study uses multiphoton microscopy to examine blood vessel dynamics and oxygen metabolism during cranial bone defect repair, revealing differential metabolic responses between endothelial cells and osteoblasts.

This study uses single-cell RNA sequencing to show that aging impairs intestinal stem cell maturation, which is reversed by metformin and rapamycin.

This study shows that CNTNAP4 signaling promotes osteosarcoma progression, and its deletion reduces tumor growth, angiogenesis, and metastasis.

The paper shows that within-host adaptation changes priority effects in the phyllosphere microbiome by altering ecological interactions and host impact.

This study shows that synthetic sensor NLR receptors require multiple interfaces within and outside their integrated domain to recognize noncorresponding effectors and activate resistance.

The paper introduces ELI-TriScope, a cryogenic system for precise cryo-lamella preparation, achieving 100% success in targeting HeLa cell centrosomes for cryo-ET structural analysis.

This study identifies ZmGL8 as a key gene regulating the balance between cuticular wax production and jasmonic acid-mediated defenses in maize, showing its role in modulating plant defense responses.