X. Zheng

This study identifies immune markers, including HLA-DR and CTLA-4 expression on CD4 T cells, that predict HBsAg loss in chronic hepatitis B patients.

This study shows that SARS-CoV-2-specific T cell memory persists for at least 9 months in most convalescent COVID-19 individuals, with some responses lasting longer.

This paper identifies a novel allele of the chromogen gene C from wild rice that regulates anthocyanin biosynthesis differently in indica and japonica subspecies.

This study examines CD8+ T cell cytotoxicity in mild COVID-19 patients, finding reduced cytotoxic potential in elderly individuals over 80 years old.

The paper identifies 9240 lncRNAs in diploid cotton using multi-omics data and reveals their transcriptional regulation and co-expression with protein-coding genes and GWAS SNPs.

This paper introduces cRASL-seq, a method for sensitive and high-throughput SARS-CoV-2 detection and genotyping without nucleic acid extraction or reverse transcription.

The paper shows that the J-protein Sis1's subcellular localization regulates the heat shock response in yeast by modulating Hsp70's interaction with Hsf1.

This study constructs a lipid metabolic map of Histoplasma capsulatum and identifies potential antifungal drug targets through pathway validation and compound testing.

Transgenic experiments show Gl2-like and Gl2 genes in maize have overlapping but divergent roles in cuticular lipid deposition, with Gl2-like requiring a catalytic motif for function.

This study identifies aberrant GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe 2019-nCoV patients, linking them to immune damage and mortality.

This paper introduces FR3AK-seq, a cost-effective method for TCR CDR3 repertoire analysis, showing it is sensitive and comparable to industry standards.

This paper introduces CRISPR-HOT, a method for efficient knock-in of exogenous DNA in human organoids without requiring homology templates or TP53 inactivation, and demonstrates its application in studying hepatocyte division and ploidy.

This study shows that cleavage of a pathogen protein by plant proteases activates immunity, while pathogens counteract this with inhibitors.

This study uses single-cell RNA sequencing to identify an endosymbiotic cell type in a soft coral and reveals its lineage dynamics during algal uptake and maintenance.

This study investigates the role of the dorsal premotor cortex (PMd) in hand gesture preparation in macaques, finding that some neurons are involved in hand shape preparation regardless of visual stimuli or selection strategies.

The paper develops and validates a high-fidelity 3D continuum model for avian voiced sound production, showing it accurately predicts vibratory and acoustic traits.

This paper shows that intranasal immunization with an MCMV-based vaccine vector induces lung-resident memory CD8+ T cells that protect against influenza challenge.

This paper shows that the bacterial T6SS effector EvpP inhibits neutrophil recruitment by suppressing Jnk-Caspy inflammasome signaling in zebrafish larvae during infection.

This study directly images the circular chromosome of live E. coli cells, revealing its torus topology and dynamic structural features.

This study characterizes PsBCAT, a branched-chain amino acid aminotransferase from Pseudomonas sp., showing broad substrate specificity and high activity, and demonstrates its application in efficient chiral amino acid synthesis.

This study develops a rapid LF-RPA assay for detecting Burkholderia pseudomallei with high specificity and sensitivity, suitable for point-of-care use.

This study shows lamin-B1 in thymic epithelial cells is reduced with aging due to inflammation, leading to thymus degeneration and impaired function.

The paper identifies MoRgs7 as a GPCR-like receptor in Magnaporthe oryzae that senses hydrophobic surfaces via hydrophobic interactions, couples with Gα subunit MoMagA for endocytosis, and promotes cAMP signaling required for appressorium formation and pathogenicity.

This study shows that spatial confinement in E. coli determines chromosome size and position, with simulations supporting depletion effects from cytosolic crowders.

This study shows that KMO inhibition protects against renal ischemia-reperfusion injury in mice by reducing renal damage and inflammation.

The paper validates a mathematical model of the yeast heat shock response by showing Hsp70-mediated negative feedback regulates Hsf1 activity through specific binding sites and domains.

The paper identifies and validates single-copy gene markers for phylogenomic studies in ray-finned fishes using comparative genomics and empirical testing across 83 species.

The paper uses genome-wide SNPs to analyze gene flow in Ae. albopictus, finding that distance from shipping terminals and isolation by distance drive genetic structure.

This study identifies 208 imprinted genes in rice, showing limited transposable element association, intraspecific variation, and conservation of imprinting at some loci across plant species.