Y. Cheng

The paper shows that the Phage Nucleus of {phi}PA3 forms a self-assembling, 2D crystalline lattice with adaptable inter-tetramer contacts and functional channels.

This study develops a miniaturized ultrasound transducer for full-mouth oral health monitoring, demonstrating high-resolution imaging and accurate gingival thickness measurement.

This study identifies TraB1 as a novel EMCS component in Arabidopsis that regulates both ER-mitochondrial tethering and mitophagy, essential for mitochondrial function and stress recovery.

AreTomo automates motion-corrected cryo-electron tomographic alignment and reconstruction, enabling high-resolution subtomogram averaging and real-time feedback during data collection.

This study combines CODEX and RNAscope to enable simultaneous detection of proteins and RNA on single tissue sections and assesses cross-reactivity of CODEX antibodies in rhesus macaques.

This study uses deep learning to infer 3D genome organization from ancient DNA, revealing how chromatin folding influenced phenotypic and sequence divergence between Neanderthals, Denisovans, and modern humans.

The paper determines the structure of mTORC2 and shows how substrate-specific interactions and conformational changes regulate its activity.

This study compares sterilization methods for fish surrogacy, finding germ cell-depleted recipients most effective for successful germ cell transplantation and reproductive output.

This study identifies DcATX1 as a histone methyltransferase that accelerates ethylene-induced petal senescence in carnation by regulating H3K4me3 levels and gene expression.

This study determines cryogenic-electron microscopy structures of active and inactive TSHR, revealing how autoantibodies and TSH activate the receptor through similar conformational changes.

The paper explores fusion protein strategies to improve cryo-EM structure determination of GPCRs without signaling proteins, achieving resolutions of 3.4 and 3.7 Å for two receptors.

CHARM study examines T cell responses in asymptomatic and symptomatic SARS-CoV-2 infected Marines, finding persistent IFN-gamma responses to S, N, and M proteins, with higher frequencies to N in asymptomatic cases.

This study uses in silico methods to analyze how disulfide bonds in SARS-CoV-2's ORF8 protein affect its structure, binding sites, and free energy when interacting with HLA-A.

This study shows SARS-CoV-2 infects neurons in the CNS of K18-hACE2 mice, with microglia not restricting viral replication but contributing to inflammation.

The paper identifies IgA-secreting AT2-like cells in fibrotic lungs and shows their role in ECM IgA deposition through spatial transcriptomics and scRNA-seq.

This study shows propionate improves diabetes-induced neurological dysfunction by enhancing cerebral microcirculation, reducing oxidative stress, and activating the PI3K/Akt/eNOS signaling pathway in diabetic mice.

The paper identifies two circRNAs whose m6A methylation synergistically promotes pulmonary fibrosis by targeting eIF4A3, mediated by METTL3.

This study identifies sporadic dissemination of tet(X3) and tet(X6) in livestock-associated Acinetobacter through diverse plasmidomes, highlighting the need for One Health surveillance.

This paper shows that CIITA upregulates MHC-I and MHC-II in transmissible cancers, with differential protein expression and functional implications for immune evasion.

This study investigates how different agonists of the NK1R receptor influence G-protein signaling through structural dynamics and extracellular loop interactions.

This study identifies a niche evolution event in Montifringilla nivalis that enabled its broad geographic distribution and altered the distributional potential of the snowfinch lineage.

ZF2001, a tandem-repeat dimeric RBD protein vaccine, induces strong immune responses and protects mice and non-human primates from SARS-CoV-2 infection.

This paper introduces a method to recognize small biomolecules through dose-effect interdependence encoded in chromatographic microassay arrays, applied to natural products for high-throughput screening.

This study shows human microglia can be reconstituted in the brain of hu-BLT mice with hIL34 transgene and support HIV-1 infection, highlighting their role in CNS HIV-1 pathogenesis.

This study identifies immune mechanisms underlying CyHV-3 resistance in a common carp strain through transcriptomic analysis of gene and lncRNA expression.

This study optimizes K3 camera settings in CDS mode for cryo-EM, showing improved resolution and throughput for protein complex imaging.

This paper develops a nanobody agonist that activates the Hedgehog pathway by stabilizing an alternative conformation of Patched1, disrupting its sterol conduit and providing a new approach for transporter-related drug development.

This paper develops covalently linked graphene oxide affinity grids for cryo-EM, enabling high-resolution reconstructions by preventing particle denaturation and aggregation.

This paper investigates how Na+ flux through DISP1 enables release of lipid-modified Hedgehog signals by analyzing structural and functional changes in DISP1 variants.

This study shows that convolutional neural networks can enhance SNR and generate contrast in cryo-EM images, improving image processing outcomes.