Y. Hu

This study identifies that BTLA and PD-1 use distinct phosphatases to differentially repress T cell signaling, highlighting mechanistic differences between two co-inhibitory receptors.

The paper shows that lateral mechanical impedance, not frontal, promotes cortical expansion and radial growth in maize roots.

This study shows that ERAD deficiency causes mitochondrial dysfunction and transcriptional changes in human hepatic cells, linking ERAD to mitochondrial health.

A purified inactivated SARS-CoV-2 vaccine candidate (PiCoVacc) induces neutralizing antibodies in animals and shows safety and partial to complete protection against SARS-CoV-2 strains.

The paper develops an in vivo platform to study secreted protein trafficking between organs, identifies interorgan communication factors, and finds conserved adipokines affecting muscle activity.

The paper introduces Drishti v2.6.6, an open-source tool for 3D segmentation of computed tomography data, and demonstrates its applications in various research fields.

This study compares SARS-CoV-2 infection outcomes in three non-human primate species, finding that M. mulatta is most susceptible, followed by M. fascicularis and C. jacchus.

This study uses scRNA-seq to identify and characterize subtypes of human BM-MSCs in vivo, revealing their heterogeneity and potential differentiation trajectories.

This study identifies direct kinase targets of Compound Danshen Dropping Pills using literature, public databases, and in silico models, finding 30 targets at 25 g/ml and 9 dose-dependent targets at 250 g/ml.

This study shows that HBV infection enhances the hexosamine biosynthesis pathway, leading to O-GlcNAcylation of SAMHD1, which boosts antiviral immunity against HBV and HIV-1.

This study shows that anethole dithiolethione improves liver fatty acid metabolism in hamsters on high-fat diets by altering fatty acid profiles and regulating key metabolic pathways.

This study investigates microbial mediation of anaerobic pyrite oxidation under circumneutral conditions and identifies ligand production as a preferred pathway over acidic micro-environments.

The paper uses single-cell RNA sequencing to analyze stomatal lineage cell development in Arabidopsis, identifying new marker genes and transcriptional networks.

The paper characterizes the complete genome of a novel coronavirus, WHCV, linked to a respiratory outbreak in Wuhan, finding it closely related to SARS-like bat coronaviruses.

This study identifies lineage reversion as a mechanism enabling WNT-independent growth in intestinal cancer by integrating genetic alterations and extracellular signals.

The paper tests UVC mutagenesis in Chlamydomonas reinhardtii grown in a spaceflight-compatible system to identify genes important for growth under artificial light conditions.

This study evaluates HT61, a quinoline derivative, showing greater efficacy than vancomycin in killing Staphylococcus aureus biofilms and disrupting their structure.

This study uses scRNA-seq to analyze Drosophila hemocytes under inflammatory conditions, revealing new states and a role for FGF signaling in immune responses.

This study cultivates exoelectrogenic bacteria in conductive DNA nanocomposite hydrogels to create a programmable biohybrid system that can release and degrade on demand.

This paper shows that Plasmodium falciparum infects reticulocytes with higher affinity, alters drug sensitivity, and remodels host cells through transcriptomic changes.

This study compares the faecal microbiomes of invasive European brown hares and European rabbits in Australia, finding significant differences in microbial composition between the species.

This study found that a significant proportion of E. coli isolates from ready-to-eat lettuce in Northern California carry beta-lactam resistance genes, posing a potential risk for human infections.

The paper analyzes non-additive effects in mixed-species litter decomposition, finding synergistic and antagonistic effects under different conditions.

The paper quantifies surface area to volume ratio dynamics in bacteria under environmental changes and develops a model linking these dynamics to gene expression and growth control.

This study shows H. pylori infection inhibits autophagy, leading to DNA damage via p62-mediated Rad51 ubiquitination in gastric cells.

This study shows that germline RNA helicases regulate P granule formation and disassembly through RNA binding and release, with FGG repeats promoting perinuclear localization, and links defects in this process to fertility issues in C. elegans.

This study uses bibliometric analysis to examine soil remediation research trends from 1988-2018, identifying key topics and institutional contributions.

This study investigates Paramecium's extreme tolerance to γ rays, finding its LD50 is 3000 Gy, 60 times higher than humans, and identifies two upregulated genes potentially involved in DNA protection.

The paper compares gut metagenomics and metaproteomics in prediabetics and treatment-naïve type 2 diabetics to identify host-microbial interplays across disease stages.

This study identifies circulating bacterial DNA biomarkers for colorectal cancer and adenoma using plasma samples and a random forest model, achieving high accuracy in distinguishing between cancer, adenoma, and healthy controls.