Y. Hu

The paper shows cancer-type specific aneuploidies correlate with normal tissue gene expression patterns, suggesting they hard-wire chromosome-wide expression levels to support tumorigenesis.

This study identifies Rnaseh2c as a metastasis susceptibility gene in breast cancer, independent of its enzymatic activity, and links it to T cell-mediated immune responses.

The paper examines geographic patterns of bacterioplankton in interconnected lakes of the Yangtze River Basin, finding that distance-decay relationships and stochastic processes dominate bacterial community assembly.

This paper develops a method to directly synthesize EM-visible gold nanoparticles on genetically encoded tags for single-molecule visualization in cells, achieving high labeling efficiency in both prokaryotic and eukaryotic cells.

The paper uses whole genome sequencing on a portable device to detect fungal pathogens and associated microbes in infected wheat, showing its effectiveness for diagnosing specific diseases.

This paper validates a low-cost cryoablation system using carbon dioxide for tumor ablation in resource-constrained settings, showing effective necrosis in rat and porcine models.

This study establishes a 240-hour co-culture biofilm model of P. aeruginosa and S. aureus, showing increased mutation rates in both species during biofilm formation.

This study uses NMR to reveal the structural basis of HdeA activation under acidic conditions, identifying key disordered regions and client binding sites.

This study investigates how N-glycans regulate platelet-collagen interactions using proteomic and glycoproteomic analysis with N-glycan manipulation.

The paper describes the discovery and characterization of a novel Klebsiella species, Klebsiella huaxiensis, isolated from a human urine sample.

This study establishes a glycoproteomic workflow to analyze N-linked glycosylation in CHO-K1 cells expressing EPO, identifying 10,338 glycopeptides and revealing atypical glycosylation sites.

This study investigates how different molecular weights of hyaluronic acid in hydrogels affect the invasive behavior of glioblastoma cells.

This study shows that ephrinB2 deficiency in osteocytes increases autophagy, leading to accelerated secondary mineralization and brittle bones.

This paper develops self-assembling all-enzyme hydrogels for biocatalytic flow processes, achieving high stereoselectivity and cofactor turnover.

This paper introduces a novel RNAi-based method called variable dose analysis (VDA) to detect synthetic lethal interactions, identifying four FDA-approved drugs for TSC-related tumors.

This study investigates the microbial communities of New World army ants, revealing specialized gut symbionts and their evolutionary history across different host species and geographic regions.

This study identifies three colorectal cancer risk loci associated with poor prognosis in rectal cancer patients and links some SNPs to chemoradiotherapy resistance.