Y. Li

This study shows mesenchymal progenitors regulate the balance between type 1 and type 2 inflammation via the TAK1-NFkB pathway, with implications for inflammatory diseases.

The paper generates and indexes an EMS mutant library for KN9204 wheat to enhance functional genomics and genetic manipulation for agronomic traits.

This study uses computational models to show that weak-rectified gap junction coupling and electrically isolated distribution of bio-pacemaker cells enhance their pacing efficiency.

This study identifies line-specific barriers to reprogramming transformed cells and shows that MEK inhibition can overcome some of these barriers by modulating the epigenetic state.

This study shows that AcrVA2 inhibits Cas12a mRNA translation, reducing its anti-phage activity and enabling specific inhibition of Cas12a orthologs.

The paper identifies ABL1 and ABL2 as new auxin receptors that function with TMKs as co-receptors for extracellular auxin, overlapping with but distinct from ABP1.

This paper identifies CX3CR1+ CD8+ T cells with low mitochondrial membrane potential as functionally resilient, showing high cytotoxicity and reduced ROS through ME1 upregulation, which enhances their anti-tumor activity.

MMR vaccination induces functional and metabolic reprogramming of γδ T cells, enhancing their activation and cytokine production.

This paper introduces a new antiviral strategy using hyperanion-grafted enediyne molecules to disintegrate viral proteins, showing effectiveness against SARS-CoV-2 and other coronaviruses.

This study shows that SnRK1 represses anthocyanin biosynthesis by inhibiting the MBW complex transcriptionally and through direct phosphorylation and dissociation of its components.

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

The paper describes how two species of flying squirrels in Hainan Island use a mortise-tenon structure to securely cache nuts on twigs to deter predation and ensure food supply.

This study shows that combining mesenchymal stromal cells and alpha-1 antitrypsin significantly improves inflammation modulation and resolution in vitro and in a mouse model.

This study uses mid-infrared spectra of milk to establish models for assessing mammalian evolutionary relationships and genetic distances with high accuracy.

CosTaL is a graph-based clustering algorithm for single-cell data that improves clustering effectiveness and scalability compared to existing methods.

This study identifies a novel catecholaminergic cardiomyocyte population expressing Dbh that contributes to the murine cardiac conduction system through transcriptomic, genetic, and optogenetic analyses.

This study identifies TNY1, a cytosolic RNA-binding protein, as a key regulator of cell size homeostasis in Chlamydomonas through subscaling, which controls division number and daughter cell size.

The paper identifies a Prunus MAX1 homolog as a strigol synthase that bypasses 5-deoxystrigol synthesis, directly converting carlactone to strigol.

The paper shows oskar works with Creb to regulate long-term memory in crickets, supporting its evolutionary origin in neural functions.

This study identifies a new class of V2-directed cross-neutralizing antibodies targeting a cryptic epitope in occluded-open HIV and SIV Env trimers.

This paper introduces FD-DeepLoc, a deep learning method for high-throughput 3D super-resolution imaging over a large field of view using a sCMOS camera.

This study develops a bioengineered FZD4-selective WNT surrogate that improves BBB function and reduces ischemic stroke damage in mice.

This paper uses cryo-EM to reveal how VX445 corrects CFTR folding and gating defects by altering allosteric communication pathways.

The paper quantifies intraROS and apoROS accumulation in wheat infected by Bgt, showing that intraROS contributes to localized cell death in NLR R gene lines, while unconventional R genes show reduced intraROS responses.

This study uses optical metabolic imaging to show diet and sex influence lipid metabolism in aging Drosophila brains, revealing IIS pathway involvement.

The paper investigates L1 retrotransposition in HGSC, finding that despite high L1 mRNA expression, only a third of tumors show somatic insertions, with variability in retrotransposition frequency and patterns.

This study investigates how metabolic acids like citrate and lactate influence the 3D architecture of bone mineral through synthetic apatite formation.

This paper identifies a microbiome guild-level signature associated with COVID-19 severity and prognosis using metagenomic analysis of fecal samples.

This study identifies a novel immune system, Juk, in Pseudomonas aeruginosa that targets jumbo phages by inhibiting early phage transcription, DNA replication, and nucleus assembly.