Y. Li

This study reprograms human fibroblasts into anti-aging neural stem cells using miR-302a, which enhance cognitive function and extend lifespan in mice with Alzheimer's.

This paper develops a deep learning method to assess chondrocyte viability using label-free two-photon microscopy images from rat and porcine cartilage, achieving 95% accuracy.

The paper identifies a non-canonical IRAK signaling pathway triggered by DNA damage that promotes anti-apoptosis and is activated by ionizing radiation and genotoxic therapies.

The paper quantifies UPF3A and UPF3B expression in mouse tissues, finding UPF3A is ubiquitously expressed, contradicting previous assumptions of limited expression.

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

The paper was withdrawn due to the need for additional experimental evidence and reorganization of data and writing.

This study shows that PIF3, a transcription factor, regulates root penetration in Arabidopsis by interacting with FER, a receptor kinase, and modulating mechanosensitive ion channels and root cap cell sloughing.

This study identifies a unique GSH utilization pathway in Francisella, revealing a pseudogenized transporter gene in pathogenic strains and its role in environmental niches.

This study shows that steamed broccoli sprouts reduce DSS-induced colitis in mice by preserving gut microbial diversity and biogeography.

This study shows that a broccoli sprout diet reduces symptoms of Crohn's-like disease in IL-10-KO mice, with stronger effects in younger mice.

This paper introduces multifunctional ferromagnetic fiber robots capable of navigation, sensing, and treatment in minimally invasive surgery, demonstrating their use in electrophysiology sensing and localized treatment.

The paper presents cryo-EM structures of human NaV1.6 channels with and without 4,9-anhydro-tetrodotoxin, revealing Na+ selectivity and inhibition mechanisms.

This study shows that Vcam1 expression in cholangiocarcinoma cells is regulated by peritumoral myofibroblasts, promoting tumor dissemination while suppressing growth.

This study shows USP39 promotes liver cancer by regulating alternative splicing through interaction with SRSF6/HNRNPC, identifying it as a potential therapeutic target.

This study uses SD-OCT to identify and quantify ovarian follicles in mice, showing agreement with histology and improved image contrast for follicle analysis.

The paper presents the Cryo-EM structure of DNA polymerase θ helicase domain with and without inhibitor novobiocin, revealing a non-canonical binding pocket and insights into its mechanism.

The paper shows quorum sensing represses the Type III-A CRISPR-Cas system in S. aureus by inhibiting SarA and ArcR, which are positive regulators of the system.

This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.

This study shows that non-canonical NF-κB activation enhances p52 binding to the ETS1 promoter, leading to ETS1 overexpression and transcriptional activation of glioma-promoting genes.

Lon1 knockout inhibits mitochondrial-encoded gene translation and induces retrograde signaling involving unfolded protein responses.

This paper develops a multivalent exosome-based vaccine using nanogram doses of SARS-CoV-2 proteins without adjuvant, showing strong immune responses and cross-reactivity against variants.

The paper identifies transcription factors driving distinct CD8+ T cell states and shows their impact on tumor control and immunotherapy.

The paper quantifies apoE glycosylation in plasma and CSF, finding associations with APOE genotype, total apoE levels, and amyloid status in older individuals.

StereoSiTE analyzes spatial transcriptomics data to identify cell-cell interactions in the tumor microenvironment and reveals neutrophil-driven communication networks in treated xenograft models.

This study identifies a regulatory axis involving acetylation and ubiquitination of Isw1 in Cryptococcus neoformans that controls multidrug resistance.

This study shows FAM76B inhibits NF-κB-mediated inflammation by affecting hnRNPA2B1 translocation in vitro and in a TBI mouse model, and identifies its interaction with hnRNPA2B1 in human TBI and neurodegenerative disease tissues.

This study identifies a mitochondrial signaling loop involving Sgk1 that regulates epithelial cell plasticity in zebrafish and human cancer cells.

This study determines the cryo-EM structure of the MPXV DNA polymerase holoenzyme F8/A22/E4, revealing its dimeric assembly and auto-inhibition state, with implications for antiviral drug design.

Open-3DSIM improves lateral and axial resolution in 3D structured illumination microscopy and offers artifact suppression and defocus elimination across various specimens.

This paper introduces OrgaTracker, a system using deep learning to track and analyze organoid growth, and generates artificial organoids from sketches.