Y. Luo

This study shows BET1 promotes GBM cell invasion by transporting MMP14 to the plasma membrane, suggesting BET1 as a potential therapeutic target.

This study identifies genes and pathways involved in vincristine resistance in DLBCL cells using CRISPR screening and shows synergistic effects of combining KIF18A inhibition with vincristine.

The paper shows that plants can distinguish between beneficial and pathogenic Pseudomonas fluorescens strains through distinct immune responses.

The paper reports the first experimentally determined structure of CMTM6 and proposes an interaction model with PD-L1, providing structural insights into its role in stabilizing the PD-1/PD-L1 axis.

This study determines the structure of RsmZ in complex with RsmA, revealing how RsmZ regulates virulence in Pseudomonas aeruginosa by modulating RsmA binding and gene expression.

This study uses hiPSC-derived organoids to show that co-exposure to microplastics and TBBPA increases toxicity in patient-derived organoids compared to healthy ones.

This study examines age-related seroprevalence of four seasonal coronaviruses in children and postpartum women, showing waning passive immunity and resurgence of IgGs with age.

The paper develops ACE2-Fc molecules that neutralize SARS-CoV-2 and show Fc-effector activity, effectively treating lethal infection in mice.

The paper presents a cryo-EM structure of ZnT8 at low pH, suggesting protons disrupt Zn2+ coordination, aiding its release into the lumen.

This study computes binding free energies of Yoda1 and its analogs at Piezo1 channels using molecular dynamics to predict agonist/inhibitor effects and guide drug design.

This study shows that overexpressing connexin43 in bone marrow-derived stromal stem cells promotes osteogenesis and angiogenesis, enhancing bone regeneration in a rat model of glucocorticoid-induced osteonecrosis.

The paper identifies potential drug targets for intestinal fibrosis by combining image-based morphology analysis with AI and inflammatory biomarker measurements.

This study analyzes the spatiotemporal patterns of scrub typhus in China from 2012 to 2018, identifying key meteorological, environmental, and socio-economic factors influencing its distribution.

This study examines how climate and ant richness influence the global distribution of three ant-plant mutualisms, revealing distinct biogeographic patterns and climate dependencies.

The paper uses organoid models to show that WNT2B promotes vascularization in pregnancies, linking trophoblast function to vascular development in both intrauterine and ectopic pregnancies.

This study identifies sustained molecular signatures in monocytes and regulatory T cells in convalescent COVID-19 patients, associated with disease severity.

This study shows that seasonality, not photoperiodism, affects the susceptibility of spider mites to pesticides, with toxicity increasing in spring and summer and decreasing in winter.

This study characterizes the antigenic properties of SARS-CoV-2 Omicron sublineages BA.1+R346K and BA.2, showing they exhibit significant antibody evasion similar to BA.1.

This study shows that RfxCas13d causes mouse death by collateral cleavage of 28s rRNA, highlighting biosafety concerns for CRISPR-Cas13 systems.

The paper reports a cryo-EM structure of the SARS-CoV-2 Omicron spike protein, revealing how mutations alter its conformation and enable antibody resistance.

This study uses single-cell RNA-sequencing to analyze immune cell diversity across 12 species, revealing conserved and divergent molecular mechanisms and cellular interactions.

This study shows that the Omicron variant of SARS-CoV-2 is highly resistant to neutralization by convalescent serum and vaccines, and many monoclonal antibodies.

The paper identifies a human monoclonal antibody that neutralizes all tested sarbecoviruses and describes a new antibody class with potential for pandemic preparedness.

The paper identifies an artifact in hybrid MD simulations of ion channel pores caused by differences in solvation and equilibrium protocols between coarse-grained and all-atom models, and proposes a solution to correct it.

The paper compares three methods for computing ion channel permeability using molecular dynamics simulations and finds they yield consistent results.

This study examines mitochondrial dysfunction in a MAFLD cell model, identifies gene expression changes, and suggests potential therapeutic targets.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study identifies lactoferrin, MUC1, and α-lactalbumin in human breastmilk as antiviral components that inhibit SARS-CoV-2 infection and replication, including variants.

This study identifies BSB, an ancestral strigolactone in bryophytes, which functions as a rhizosphere signal for AM symbiosis and was later co-opted as a plant hormone.